کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7592958 | 1492115 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources
ترجمه فارسی عنوان
پاسخ سلولهای تک سلولی خون محیطی از بیماران حساس به گلوتن غیر سلیاک به منابع مختلف غلات
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Non-celiac gluten sensitivity (NCGS) is still an undefined syndrome whose triggering mechanisms remain unsettled. This study aimed to clarify how cultured peripheral blood mononucleated cells (PBMC) obtained from NCGS patients responded to contact with wheat proteins. Results demonstrated that wheat protein induced an overactivation of the proinflammatory chemokine CXCL10 in PBMC from NCGS patients, and that the overactivation level depends on the cereal source from which proteins are obtained. CXCL10 is able to decrease the transepithelial resistance of monolayers of normal colonocytes (NCM 460) by diminishing the mRNA expression of cadherin-1 (CDH1) and tight junction protein 2 (TJP2), two primary components of the tight junction strands. Thus, CXCL10 overactivation is one of the mechanisms triggered by wheat proteins in PBMC obtained from NCGS patients. This mechanism is activated to a greater extent by proteins from modern with respect to those extracted from ancient wheat genotypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 176, 1 June 2015, Pages 167-174
Journal: Food Chemistry - Volume 176, 1 June 2015, Pages 167-174
نویسندگان
Maria Chiara Valerii, Chiara Ricci, Enzo Spisni, Raffaella Di Silvestro, Luigia De Fazio, Elena Cavazza, Alberto Lanzini, Massimo Campieri, Alessandro Dalpiaz, Barbara Pavan, Umberto Volta, Giovanni Dinelli,