کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7594385 | 1492119 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids
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کلمات کلیدی
Melatonin (PubChem CID: 896)IndolesDeoxyribose8-hydroxy-2′-deoxyguanosine - 8-هیدروکسی-2'-دگزسی گوانوزینTetrahydro-β-carbolines - tetrahydro-β-carbolinesβ-Carboline alkaloids - آلکالوئیدهای β-کاربولینAntioxidants - آنتی اکسیدانBenzoate - بنزواتMelatonin - ملاتونینhydroxyl radical scavengers - هیدروکسیل رادیکال پراکنده
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids](/preview/png/7594385.png)
چکیده انگلیسی
β-Carbolines are bioactive pyridoindole alkaloids occurring in foods, plants and the human body. Their activity as hydroxyl radical (OH) scavengers is reported here by using three different methods: deoxyribose degradation, hydroxylation of benzoate and hydroxylation of 2â²-deoxyguanosine to give 8-hydroxy-2â²-deoxyguanosine (8-OHdG) as assessed by RP-HPLC (MS). Fenton reactions (Fe2+/Fe3+ plus H2O2) were used for OH generation, and the radical increased in the presence of ascorbic acid or 6-hydroxydopamine as pro-oxidants. β-Carbolines were scavengers of OH in the three assays and in the presence of pro-oxidants. Tetrahydro-β-carboline-3-carboxylic acids were active against the hydroxylation of 2â²-deoxyguanosine. β-Carbolines reacted with hydroxyl radicals (OH) affording hydroxy-β-carbolines, whereas tetrahydro-β-carbolines gave oxidative and degradation products. On the basis of IC50 and reaction rates (k), β-carbolines (norharman and harman), and tetrahydro-β-carbolines (tetrahydro-β-carboline, 1-methyltetrahydro-β-carboline and pinoline) were good OH radical scavengers and their activity was comparable to that of the indole, melatonin, which is an effective hydroxyl radical scavenger and antioxidant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 172, 1 April 2015, Pages 640-649
Journal: Food Chemistry - Volume 172, 1 April 2015, Pages 640-649
نویسندگان
Tomás Herraiz, Juan Galisteo,