Composition of distilled Perique tobacco liqueur: A connoisseur's spirit or a health risk due to nicotine?

- A liqueur based on distilled tobacco leaves has been chemically characterised for the first time.
- Targeted and non-targeted analyses using multiple chromatographic and spectroscopic approaches were applied.
- Toxicologically relevant compounds were not identified, specifically nicotine was not detectable.
- Nicotine can be effectively separated during spirit distillation.