Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus

► We identified hyperoside as a major compound of Acanthopanax sessiliflorus. ► We used JB6 P + cells and UVB model. ► Hyperoside inhibits ERK1/2 activity by direct binding with ERK1/2. ► Hyperoside inhibits UVB-induced AP-1 transcritpion factor activity. ► Hyperoside inhibits UVB-induced ERK1/2 down-stream signalling.