کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7606193 1492313 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EX1 hydrogen-deuterium exchange in an all-helical protein and its cyclized derivative at neutral pH
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
EX1 hydrogen-deuterium exchange in an all-helical protein and its cyclized derivative at neutral pH
چکیده انگلیسی
► The all-helical protein, DnaBN, exhibited EX1 type hydrogen exchange at pH 7.2. ► The protein was cyclized by joining the N- and C-termini through peptide linkers that were three, four, five or nine amino acids long. ► The rate of exchange for the slowly exchanging protons decreased for both the linear and cyclized proteins as linker length increased, correlating with predictions that the C-terminal helix of the protein would be extended by addition of these extra amino acids and stabilizing the protein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Mass Spectrometry - Volume 302, Issues 1–3, 30 April 2011, Pages 149-156
نویسندگان
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