کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7638738 | 1494808 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum concentrations of trace elements and their relationships with paraoxonase-1 in morbidly obese women
ترجمه فارسی عنوان
غلظت سرمی عناصر کمیاب و ارتباط آنها با پاراکسوناز 1 در زنان دارای چاقی مفرط
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کلمات کلیدی
HOMA-IRTBBLNAFLDT2DMPON1NASDTNBVIPHDLPCA - PCANon-alcoholic steatohepatitis - استئاتوهپاتیت غیرالکلیvariable importance in projection - اهمیت متغیر در طرحDiabetes - بیماری قندnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیPrincipal component analysis - تحلیل مولفههای اصلی یا PCAType II diabetes mellitus - دیابت نوع دومMetabolic syndrome - سندرم متابولیکbody mass index - شاخص توده بدنBMI - شاخص توده بدنیICP-MS - طیفسنجی جرمی پلاسمای جفتشده القاییinductively coupled plasma mass spectrometry - طیفسنجی جرمی پلاسمای جفتشده القاییTrace elements - عناصر ردیابیHigh-density lipoproteins - لیپوپروتئینهای با چگالی بالاMETS - متسObesity - مرض چاقیNAFLD activity score - نمره فعالیت NAFLDNash - نوشParaoxonase-1 - پاراکسوناز-1Minerals - کانی، مواد معدنی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The metabolic alterations associated with obesity include mineral dysregulation. Essential trace elements are nutrients with a relevant function in a large number of cellular processes and multiple roles in the correct functioning of metabolic enzymes. Paraoxonase-1 (PON1) is an antioxidant and anti-inflammatory enzyme that is compromised in obesity. In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver. We recruited 41 morbidly obese women and 51 control individuals. The serum concentrations of 30 elements, PON1 paraoxonase and lactonase activities, and PON1 concentration were measured. We observed significant alterations in the levels of As, Ba, Cu, Ca, Fe, Mg, Na, Se, Sr, and Zn in obese women; some of them (As, Ca, Cr, Cu, Mg, and Se) being significantly correlated with serum PON1 values. The most relevant changes were observed in the concentrations of As, Sr and Mg, the last of which was also significantly associated with diabetes mellitus. The current results raise the possibility that increased ingestion and/or storage of a number of trace elements may be factors predisposing to obesity-related comorbidities and metabolic alterations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 48, July 2018, Pages 8-15
Journal: Journal of Trace Elements in Medicine and Biology - Volume 48, July 2018, Pages 8-15
نویسندگان
Fedra Luciano-Mateo, Noemà Cabré, Martà Nadal, Anabel GarcÃa-Heredia, Gerard Baiges-Gaya, Anna Hernández-Aguilera, Jordi Camps, Jorge Joven, José Luis Domingo,