کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7641095 | 1494864 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studying the interaction between peptides and polymeric nanoparticles used as pseudostationary phase in capillary electrochromatography
ترجمه فارسی عنوان
بررسی اثر متقابل پپتیدها و نانوذرات پلیمری که به عنوان فاز شبه موقت در الکتروکروماتوگرافی مویرگی استفاده می شود
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کلمات کلیدی
الکترو کروماتوگرافی مویرگی، الکتروفورز مویرگی، پپتیدها، مراحل شبه گرا، ذرات، اثر متقابل،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
In this work, the interaction between synthetic bioactive peptides and polymeric nanoparticles (NPs) used as pseudostationary phase in capillary electrochromatography was studied. NPs were prepared from methacrylic acid and ethylenglycol dimethacrylate with benzoyl peroxide by utilizing a precipitation polymerization technique. The reaction was monitored by infrared spectroscopy. Polymer characterization was performed by dynamic light scattering and transmission electron microscopy. Experimental running conditions were tested, including organic solvent proportion in the background electrolyte, capillary conditioning, applied voltage, sample introduction amount, and how NPs were incorporated into the system. A continuous full filling technique in which the NPs were suspended in the entire electrolyte volume as well as a conventional partial filling technique were used. Results obtained at pHÂ 7.0 suggest that the NPs have a very strong interaction with more basic peptides. The interaction between analytes and NPs was found to be predominantly ionic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 130, January 2017, Pages 153-156
Journal: Microchemical Journal - Volume 130, January 2017, Pages 153-156
نویسندگان
Denise A. Grela, Valeria Zannoni, Nora M. Vizioli,