Probing the micellar properties of Quinacrine 2HCl and its binding with surfactants and Human Serum Albumin

Surface tension and conductivity data was employed to detect the critical micelle concentration (CMC) and to calculate its surface and thermodynamic parameters. UV/Visible spectroscopy was used to calculate partition coefficient (Kx), free energy of partition and number of drug molecules per micelle. Fluorescence spectroscopy used to calculate values of drug-protein binding constant, number of binding sites and free energy of binding.