Synthesis of quaternary 8-(1-acylethene-1-yl)-13-methylcoptisine chlorides and their selective growth inhibitory activity between human cancer cell lines and normal intestinal epithelial cell-6

Quaternary 8-(1-acylethene-1-yl)-13-methylcoptisine chlorides targeting TrxRs were designed and synthesized. An in vitro evaluation for the growth inhibitory activities against cancer cell lines and for the viability of the normal intestinal epithelial cell-6 cell line is reported.