Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit

Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 28, Issue 17, 15 September 2018, Pages 2939-2944

Hui Qiu, Lesley Liu-Bujalski, Richard D Caldwell, Ariele Viacava Follis, Anna Gardberg, Andreas Goutopoulos, Roland Grenningloh, Jared Head, Theresa Johnson, Reinaldo Jones, Igor Mochalkin, Federica Morandi, Constantin Neagu, Brian Sherer,