Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies

Three series of novel sulfonamides incorporating substituted isatin moieties linked to benzenesulfonamide through hydrazide linkers were synthesized and evaluated for their inhibitory activity against a panel of carbonic anhydrase isoforms hCA I, II, IX and XII. 10b emerged as a single-digit nanomolar hCA IX and XII inhibitor (8.9 and 9.2 nM, respectively). Molecular docking studies were carried out for 10b within the hCA II, IX and XII active sites.265