An iridium (III) complex as potent anticancer agent induces apoptosis and autophagy in B16 cells through inhibition of the AKT/mTOR pathway

A new iridium (III) complex was synthesized and characterized. The apoptosis, comet assay, ROS, mitochondrial membrane potential, cell invasion, intracellular Ca2+ level, release of cytochrome c, cell cycle arrest and Bcl-2 family proteins expression were studied.213