کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7797619 | 1501092 | 2016 | 57 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design](/preview/png/7797619.png)
چکیده انگلیسی
New series of indazole-based derivatives were synthesized and structure-activity relationship was constructed. Hit compound from sub-structure search, followed by in silico fragment-based drug design and knowledge-based drug design to discover compound 17 as a potent novel Aurora kinases inhibitor.212
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 124, 29 November 2016, Pages 186-199
Journal: European Journal of Medicinal Chemistry - Volume 124, 29 November 2016, Pages 186-199
نویسندگان
Chun-Feng Chang, Wen-Hsing Lin, Yi-Yu Ke, Yih-Shyan Lin, Wen-Chieh Wang, Chun-Hwa Chen, Po-Chu Kuo, John T.A. Hsu, Biing-Jiun Uang, Hsing-Pang Hsieh,