Keywords: ساختار-فعالیت (SAR); Nuclear receptors; PPARδ; Structure-activity relationship (SAR); ADMET; PK;
مقالات ISI ساختار-فعالیت (SAR) (ترجمه نشده)
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Keywords: ساختار-فعالیت (SAR); Norovirus; Flavonoid; Antiviral; Structure-activity relationship (SAR); Feline calicivirus (FCV);
Keywords: ساختار-فعالیت (SAR); 1,1-Diaryltertiary alcohol; Fungicidal activity; Structure-activity relationship (SAR);
The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core
Keywords: ساختار-فعالیت (SAR); M1; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-Activity Relationship (SAR);
Evidence of a reverse side-chain effect of tris(pentafluoroethyl)trifluorophosphate [FAP]-based ionic liquids against pathogenic bacteria
Keywords: ساختار-فعالیت (SAR); Reverse side-chain effect; Antimicrobial activity; Bacteria; Ionic liquids; Toxicity; Structure-activity relationship (SAR);
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay
Keywords: ساختار-فعالیت (SAR); FLIPR; Fluorescence Imaging Plate Reader; STIM1; stromal interaction molecule 1; ER; endoplasmic reticulum; TNBC; triple negative breast cancer; SAR; structure activity relationship; LHS; left hand side; RHS; right hand side; THF; tetrahydrofuran; i-PrOH;
5-Acetyl-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones: As potent urease inhibitors; synthesis, in vitro screening, and molecular modeling study
Keywords: ساختار-فعالیت (SAR); Dihydropyrimidinone; Synthesis; Urease enzyme; In vitro; Structure-activity relationship (SAR); In silico;
3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents
Keywords: ساختار-فعالیت (SAR); Acridine derivatives; Synthesis; DNA binding; Anticancer activity; Structure-activity relationship (SAR); Apoptosis;
Reactions of OH radicals with 2-methyl-1-butyl, neopentyl and 1-hexyl nitrates. Structure-activity relationship for gas-phase reactions of OH with alkyl nitrates: An update
Keywords: ساختار-فعالیت (SAR); Alkyl nitrates; OH; Kinetics; Atmospheric lifetime; Structure-activity relationship (SAR);
Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120
Keywords: ساختار-فعالیت (SAR); HIV-1; ENV-pseudovirus; Virus entry antagonist; Broad spectrum; Structure-activity relationship (SAR); “CH2OH” switch hypothesis; ADMET; HIV-1; Human Immunodeficiency Virus Type 1; Env; Envelope; AIDS; acquired immunodeficiency syndrome; VSV-G; Vesicu
2-Aryl benzimidazoles: Synthesis, In vitro α-amylase inhibitory activity, and molecular docking study
Keywords: ساختار-فعالیت (SAR); Benzimidazole; α-Amylase; In vitro; In silico; Structure-activity relationship (SAR);
Structure-activity relationships of HDAC8 inhibitors: Non-hydroxamates as anticancer agents
Keywords: ساختار-فعالیت (SAR); Vorinostat (PubChem CID: 5311); Romidepsin (PubChem CID: 5352062); PCI-34051 (PubChem CID: 24753719); Cancer; Histone deacetylase; HDAC8 inhibitor; Non-hydroxamates; Zinc binding group; Structure-activity relationship (SAR);
Toxicity and structure-activity relationship (SAR) of α,β-dehydroamino acids against human cancer cell lines
Keywords: ساختار-فعالیت (SAR); Dehydroamino acids; Toxicological profile; Apoptosis; Caspases; Therapeutic agents; Structure-activity relationship (SAR);
Design, synthesis and biological screening of 2-aminobenzamides as selective HDAC3 inhibitors with promising anticancer effects
Keywords: ساختار-فعالیت (SAR); B16F10; murine melanoma cells; CDCl3; deuterated chloroform; CTCL; cutaneous T-cell lymphoma; DCM; dichloromethane; DFT; density functional theory; DMAP; 4-Dimethylaminopyridine; DMEM; Dulbecco's modified Eagle's media; DMF; dimethylformamide; DMSO; dimet
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype
Keywords: ساختار-فعالیت (SAR); Pyrimidine; Muscarinic acetylcholine receptor; pan-Antagonist; DMPK; Structure-activity relationship (SAR);
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Keywords: ساختار-فعالیت (SAR); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-activity relationship (SAR);
Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies
Keywords: ساختار-فعالیت (SAR); M5; Muscarinic acetylcholine receptor; Pharmacokinetics; CNS penetration; Structure-Activity Relationship (SAR);
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists
Keywords: ساختار-فعالیت (SAR); Pyridazine; Muscarinic acetylcholine receptor; pan-Antagonist; DMPK; Structure-activity relationship (SAR);
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core
Keywords: ساختار-فعالیت (SAR); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Non-human primate (NHP); Structure-activity relationship (SAR);
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
Keywords: ساختار-فعالیت (SAR); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Non-human primate (NHP); Structure-Activity Relationship (SAR);
Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies
Keywords: ساختار-فعالیت (SAR); BIODS; Metronidazole; Synthesis; α-amylase; In vitro; In silico; Structure-activity relationship (SAR);
Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors: Optimization of the terminal phenyl moiety of oxazolidone derivatives
Keywords: ساختار-فعالیت (SAR); N-acylethanolamine acid amidase (NAAA); Palmitoylethanolamide (PEA); NAAA inhibitor; Oxazolidone derivatives; Structure-activity relationship (SAR);
Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1
Keywords: ساختار-فعالیت (SAR); organic anion-transporting polypeptide transporters; drug effects; structure-activity relationship (SAR); pharmacokinetics; transport; pharmacodynamics; 6-CF; 6-carboxyfluorescein; ARB; angiotensin receptor blocker; CysLT-R; cysteinyl leukotriene receptor
Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors
Keywords: ساختار-فعالیت (SAR); Dengue virus NS2B-NS3 protease inhibitor; pyrrolidino[1,2-c]imidazolidinone; Stereochemistry; Substitution and substituent; Linker; Structure-activity relationship (SAR); HQRJJHXKCFABSI-KBPBESRZSA-N; HQRJJHXKCFABSI-KBPBESRZSA-N;
Synthesis and structure-activity relationships of novel fused ring analogues of Q203 as antitubercular agents
Keywords: ساختار-فعالیت (SAR); Tuberculosis; Imidazo[1,2-a]pyridine-3-carboxamide (IPA); Pharmacokinetics (PK); Structure-activity relationship (SAR); Q203;
Synthesis and structure-activity studies of side chain analogues of the anti-tubercular agent, Q203
Keywords: ساختار-فعالیت (SAR); Tuberculosis; Imidazo[1,2-a]pyridine-3-carboxamide (IPA); Pharmacokinetics; Structure-activity relationship (SAR); Q203;
Arylsulfonamides and selectivity of matrix metalloproteinase-2: An overview
Keywords: ساختار-فعالیت (SAR); Metalloenzyme; Matrix metalloproteinase-2; Zinc binding group; Selectivity; Arylsulfonamide; Structure-activity relationship (SAR);
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists
Keywords: ساختار-فعالیت (SAR); CRTh2 antagonist; Receptor residence time; Structure-activity relationship (SAR); Structure-kinetic relationship (SKR);
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design
Keywords: ساختار-فعالیت (SAR); Aurora kinases inhibitor; Indazole; Ligand efficiency; Isoform selectivity; Structure-activity relationship (SAR);
Migration of cyclo-diBA from coatings into canned food: Method of analysis, concentration determined in a survey and in silico hazard profiling
Keywords: ساختار-فعالیت (SAR); Epoxy can coatings; Canned fish in oil; Exposure estimation; Prediction of oral bioavailability; Structure-activity relationship (SAR);
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation
Keywords: ساختار-فعالیت (SAR); Cholinesterase inhibitors (ChEIs); Acetylcholinesterase (AChE); Butyrylcholinesterase (BuChE); Human acetylcholinesterase (hAChE); Structure-activity relationship (SAR); Amyloid-β (Aβ); 5,5′-Dithiobis(2-nitrobenzoic acid) (DTNB)
Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives
Keywords: ساختار-فعالیت (SAR); Pyridines; Hydrazide hydrazones; Urea and thiourea derivatives; Anti-microbial and antifungal activities; Structure-activity relationship (SAR)
Topical Corticosteroids, Structure-Activity and the Glucocorticoid Receptor: Discovery and Development-A Process of ''Planned Serendipity''
Keywords: ساختار-فعالیت (SAR); synthesis; structure-activity relationship (SAR); in vitro/in vivo correlations (IVIVC); transdermal; receptors;
Structures and Anticancer Activities of a Series of Isomeric Complexes
Ru(azpy)2Cl2
Keywords: ساختار-فعالیت (SAR); Ru(II) isomeric complex; Anticancer activity; Phenylazopyridine (azpy); Density functional theory (DFT); Structure-activity relationship (SAR);