Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists

Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 27, Issue 15, 1 August 2017, Pages 3576-3581

Aaron M. Bender, Rebecca L. Weiner, Vincent B. Luscombe, Sonia Ajmera, Hyekyung P. Cho, Sichen Chang, Xiaoyan Zhan, Alice L. Rodriguez, Colleen M. Niswender, Darren W. Engers, Thomas M. Bridges, P. Jeffrey Conn, Craig W. Lindsley,