Keywords: Capillary UPLC; Bioanalysis; DMPK; Tienilic acid; Metabolites;
مقالات ISI (ترجمه نشده)
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Keywords: Childhood myotonic dystrophy; Clinical evolution; Clinical manifestations; Excessive daytime sleepiness; Quality of life; CDM1; Congenital Myotonic Dystrophy; DM1; Myotonic Dystrophy Type 1; DMPK; Dystrophia Myotonica protein kinase; ESS; Epworth Sleepine
Keywords: ADME; absorption distribution metabolism excretion; AFE; average fold error; CLint; intrinsic metabolic clearance; CRO; contract research organisation; CYP; cytochrome P450; DMPK; drug metabolism and pharmacokinetics; G6P; glucose-6-phosphate; t1/2; half-
Keywords: plasma protein binding; fraction unbound; drug-drug interaction; AUC; area under the curve; AUCR; area under the curve ratio; AAG; alpha 1-acid glycoprotein; CYP; cytochrome P450; BSA; bovine serum albumin; CRO; contract research organization; CV; coeffic
Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; AUC; area under the curve; BnSH; benzyl mercaptan; Xantphos; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3
Keywords: ADME-Tox; absorption, distribution, metabolism, excretion, and toxicity; CYP2C19; hepatic cytochrome P450 2C19; CYP3A4; hepatic cytochrome P450 3A4; DSC; differential scanning calorimetry; DIBAL-H; diisobutylaluminium hydride; DME; 1,2-dimethoxyethane; DM
Keywords: biliary excretion; hepatocytes; ADME; hepatobiliary disposition; cell culture; tissue engineering; toxicology; membrane transport/transporters; disposition; metabolism; 3D; 3-dimensional; 3D-HLT; 3D-bioprinted human liver tissue; APAP; acetaminophen; DMPK
Keywords: GSH; glutathione; LC/MS; liquid chromatography/mass spectrometry; MRM; multiple reaction monitoring; HRMS; high resolution mass spectrometry; Qtrap; triple quadrupole linear ion trap; EMS; enhanced MS; NL; neutral loss scan; PI; precursor ion scan; MIM; m
Keywords: Plasmodium falciparum; Malaria; Medicinal chemistry; Phenotypic hit; DMPK; drug metabolism and pharmacokinetics; SAR; structure-activity relationship; WHO; World Health Organisation; WHO-TDR; World Health Organisation Programme for Research and Training i
Keywords: AAT; alpha-1 antitrypsin (alpha-1 proteinase inhibitor, α-1 PI); AATD; alpha-1 antitrypsin deficiency; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; BE; bronchiectasis; CF; cystic fibrosis; COPD; chronic obstructive pulmonary disease
Keywords: ADME; DMPK; disposition; distribution; partition coefficients; pharmacokinetics; tissue distribution; toxicology; volume of distribution; safety assessment;
Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity
Keywords: Benzoxazole; A2A receptor; DMPK; Neurodegenerative disease;
Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors
Keywords: MAP; mitogen-activated protein; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; RA; rheumatoid arthritis; IBD; inflammatory bowel disease; COPD; chronic obstructive pulmonary disease; LPS; lipopolysaccharide; DMPK; drug metabolism and pharmacok
1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity
Keywords: Dihydrofolate reductase (DHFR); Antimycobacterial agent; Tuberculosis (TB); 1,3,5-triazaspiro[5.5]undeca-2,4-diene; DHFR; dihydrofolate reductase; DMPK; drug metabolism and pharmacokinetics; FRLM; female rat liver microsomes; HBA; hydrogen bond acceptors;
Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mech
Keywords: DMPK; hepatocytes; IVIVC; PBPK modeling; pharmacokinetics; unbound fraction;
In silico toxicity profiling of natural product compound libraries from African flora with anti-malarial and anti-HIV properties
Keywords: 2D; two dimensional; 3D; three dimensional; Afro-HIV; dataset of molecules from African flora with known activities against the human immunodeficiency virus; AfroMalariaDb; dataset of anti-malarial compounds from African flora; DMPK; drug metabolism and p
Modelling the pathogenesis of Myotonic Dystrophy type 1 cardiac phenotype through human iPSC-derived cardiomyocytes
Keywords: Myotonic Dystrophy type 1 (DM1); Human induced pluripotent stem cells; Cardiomyocytes; Electrophysiological analysis; Antiarrhytmic drugs; ACTN2; sarcomeric alpha actinin; AFM; atomic force microscopy; AP; action potential; APD; action potential duration;
AGC kinases, mechanisms of regulation âand innovative drug development
Keywords: AGC kinase; group of kinases related to PKA PKG and PKC; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PRK; protein kinase C related kinase (also termed PKN protein kinase N); PDK1; 3-phosphoinositide-dependent protein kinase 1; PKB
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype
Keywords: Pyrimidine; Muscarinic acetylcholine receptor; pan-Antagonist; DMPK; Structure-activity relationship (SAR);
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists
Keywords: Pyridazine; Muscarinic acetylcholine receptor; pan-Antagonist; DMPK; Structure-activity relationship (SAR);
A case of very long longitudinally extensive transverse myelitis (LETM) with necrotizing Vasculitis
Keywords: ACE; angiotensin converting enzyme; ADEM; acute disseminated encephalo myelitis; AQP4; aquaporin 4; BCG; Bacillus Calmette-Guérin; BHL; bilateral hilar lymphadenopathy; CD; cluster of differentiation; CSF; cerebrospinal fluid; CT; computed tomography;
Trinucleotide-repeat expanded and normal DMPK transcripts contain unusually long poly(A) tails despite differential nuclear residence
Keywords: Nuclear retention; Hyperadenylation; DMPK; Poly(A) tail; Myotonic dystrophy; Trinucleotide repeat instability; RNA processing;
Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors
Keywords: Tankyrase inhibitors; PARP family; Wnt/β-catenin signaling pathway; Wnt pathway disruption; Wnt-driven cancers; APC; adenomatous polyposis coli gene product; ARTD; ADP-ribosyltransferases; CK1; casein kinase 1; DMPK; drug metabolism and pharmacokinetics;
Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization
Keywords: AGC; protein kinase A, G, and C families (PKA, PKC, PKG) of cytoplasmic serine/threonine kinases; AnxA; vertebrate annexin; ALP; alkaline phosphatase; ANK; progressive ankylosis protein; BMP; bone morphogenetic protein; BSP; bone sialoprotein; CHOL; chole
Whole-Exome Sequencing as a Diagnostic Tool in a Family With Episodic Ataxia Type 1
Keywords: DMPK; myotonic dystrophy protein kinase gene; EA1; episodic ataxia type 1; EEG; electroencephalography; EMG; electromyography; HTT; huntingtin gene; MRI; magnetic resonance imaging; WES; whole-exome sequencing;
Haplotype analysis and LD detection at DM1 locus
Keywords: DM1; Myotonic dystrophy type 1; DMPK; Dystrophia myotonica protein kinase gene; SNPs; Single nucleotide polymorphisms; LD; Linkage disequilibrium; Myotonic dystrophy type 1 (DM1); DMPK gene; Haplotype; HhaI; HinfI; BpmI; CKMM; Linkage disequilibrium (LD);
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities
Keywords: ACAT; acyl CoA:cholesterol acyltransferase; ADME; absorption, distribution, metabolism and excretion; APCI; atomospheric pressure chemical ionization; CM; chylomicron; dba; dibenzylideneacetone; CYP; cytochrome P450; DDI; drug-drug interaction; DGAT; ac
Coupling ultra-high-pressure liquid chromatography with mass spectrometry for in-vitro drug-metabolism studies
Keywords: ADC; Analog-to-digital converter; ADMET; Absorption, distribution, metabolism, excretion and toxicity; APCI; Atmospheric pressure chemical ionization; CYP; Cytochrome P450; DDI; Drug-drug interaction; DMPK; Drug metabolism and pharmacokinetics; DT; Dwell
Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists
Keywords: Orexin antagonists; DORA; 7TM; DMPK; TDI;
Regulation of the alternative splicing of sarcoplasmic reticulum Ca2+-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway
Keywords: SERCA1; sarcoplasmic reticulum Ca2+-ATPase1; PMA; phorbol 12-myristate 13-acetate; DM1; myotonic dystrophy type 1; DMPK; myotonic dystrophy protein kinase; MBNL1; muscleblind-like protein 1; CUGBP1; CUG-binding protein 1; CELF; CUG-BP and ETR-3-like (embr
Fast mouse PK (Fast PK): A rapid screening method to increase pharmacokinetic throughput in pre-clinical drug discovery
Keywords: PK; pharmacokinetics; PD; pharmacodynamics; PO; per oral; IV; intravenous; HTS; high throughput screening; DMPK; drug metabolism and pharmacokinetics; AUC; area under the curve; HPMC; hydroxypropylmethyl cellulose; CMC; carboxymethyl cellulose; Pharmacoki
Upgrading molecular diagnostics of myotonic dystrophies: Multiplexing for simultaneous characterization of the DMPK and ZNF9 repeat motifs
Keywords: DMPK; Expansion; Myotonic dystrophy type 1; Myotonic dystrophy type 2; Repeat-primed PCR; ZNF9
IgG deficiency and expansion of CTG repeats in myotonic dystrophy
Keywords: DM1; myotonic dystrophy type I; DMPK; myotonic dystrophy protein kinase; FcRn; fragment c Receptor neonatal; IgA; immunoglobulin A; IgG; immunoglobulin G; IgGm; immunoglobulin G subclass m; IgM; immunoglobulin M; MHC; major histocompatibility; PaO2; arter
Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89
Keywords: AKAPs; anchoring kinase cAMP proteins; BSA; bovine serum albumin; DMPK; myotonin protein kinase; KCN; potassium cyanide; PCP; pentachlorophenol; PDVF; poly (vinylidene difluoride); PKA; protein kinase cAMP dependent; PKC; protein kinase C; PKI; protein ki
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents
Keywords: HCV; NS3/4A protease; Inhibitors; P2 substituent; Quinazoline; Replicon assay; In vitro; DMPK; In vivo PK;
Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK)
Keywords: DMPK; Protein–protein interaction; Mass spectrometry; Non-denaturing electrophoresis; Co-immunoprecipitation; αB-crystallin/HSPB5; HSP25/HSPB1
Measurement of the pharmacokinetics and pharmacodynamics of neuroactive compounds
Keywords: Microdialysis; Receptor occupancy; Pharmacokinetics; Pharmacodynamics; Drug safety; Drug efficacy; DMPK; CNS disorder;
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: Structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides
Keywords: HCV; Polymerase; NS5B; Diels–Alder; DMPK
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration
Keywords: 5-HT; GPCR; Guanidine; DMPK; Molecular properties
The effect of myotonic dystrophy transcript levels and location on muscle differentiation
Keywords: Myotonic dystrophy; Muscle cell differentiation; WPRE; DMPK
Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1
Keywords: Myotonic dystrophy; DMPK; Neuromuscular disease
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems
Keywords: Rat; D3 antag; SAR; DMPK; In vitro; In vivo; Selective
Ribonuclear foci at the neuromuscular junction in myotonic dystrophy type 1
Keywords: Myotonic dystrophy; DMPK; Dystrophia myotonica kinase; MBNL1; Muscleblind; Neuromuscular junction; Subsynaptic nuclei; RNA disease
Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cells
Keywords: Ca2+ channels; CTG repeats; Myotonic dystrophy; DMPK; Real-time RT-PCR; Stargazin
Myotonic dystrophy: Emerging mechanisms for DM1 and DM2
Keywords: Myotonic dystrophy; Repeat expansion; DMPK; ZNF9; MBNL; CUG-BP
Inhibitors of epidermal growth factor receptor tyrosine kinase: Optimisation of potency and in vivo pharmacokinetics
Keywords: EGF; Kinase; Inhibitor; DMPK
Human myotonic dystrophy protein kinase effect in S. cerevisiae
Keywords: DM; Myotonic dystrophy; DMPK; myotonic dystrophy protein kinase; DMFL; full-length myotonic dystrophy; DMT; truncated myotonic dystrophy; S. cerevisiae; DMPK; CBK; Polarized growth;
Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant
Keywords: DM1; myotonic dystrophy type1; DM2; myotonic dystrophy type2; DMPK; DM1 protein kinase; 3â²-UTR; 3â²-untranslated region; RT-PCR; reverse transcription polymerase chain reaction; MW; molecular weight; kDa; kilo-Dalton; EtBr; ethidium bromide; conc.; con
Drug Metabolism and Pharmacokinetics, the Blood-Brain Barrier, and Central Nervous System Drug Discovery
Keywords: Blood-brain barrier; CNS drug discovery; DMPK; pharmacokinetics; pharmacodynamics; microdialysis; MDCK cells; in silico prediction of brain permeation; aging; brain disorders;