Regulation of the alternative splicing of sarcoplasmic reticulum Ca2+-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway

► PMA regulates endogenous SERCA1 splicing in HEK293 cells. ► PMA's effects were completely abolished by the PKC inhibitor Ro 31-8220. ► PKCβII and PKCθ are the specific PKC isozymes regulating SERCA1 splicing.