Keywords: گیرنده استیل کولین muscarinic; Autonomic nervous system; Sympathectomy; Endocrine pancreas; Insulin release; Metabolism; Alpha-2 adrenergic receptor; 4-DAMP; 4-diphenylacetoxy-N-methylpiperidine methiodide; ACh; acetylcholine; α2AR; alpha-2 adrenergic receptor; ADRA2A; alpha-2 adrener
مقالات ISI گیرنده استیل کولین muscarinic (ترجمه نشده)
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Keywords: گیرنده استیل کولین muscarinic; Opioids; Analgesia; Adverse effects; Mechanisms; Constipation; Nausea; Vomiting; Respiratory depression; 5-HT; 5-hydroxytryptamine; 7TMRs; 7-transmembrane spanning G-protein coupled receptors; AC; adenylyl cyclase; β-arr1; β-arrestin1; β-arr2; β-arres
Keywords: گیرنده استیل کولین muscarinic; Oxotremorine (Pubchem CID: 4630); Atropine sulfate (Pubchem CID: 5927); (+/-)-epibatidine dihydrochloride (PubChem CID: 16219300); Mecamylamine hydrochloride (PubChem CID: 13221); Capsaicin (Pubchem CID: 1548943); Normal saline (PubChem: 5234); Capsaicin;
Keywords: گیرنده استیل کولین muscarinic; ACh; acetylcholine; ANOVA; analysis of variance; CNV; contingent negative variation; DA; dopamine; FP; fixation point; mAChR; muscarinic acetylcholine receptor; MI; modulation index; MR; magnetic resonance; MS; memory-guided saccade; nAChR; nicotinic acet
Keywords: گیرنده استیل کولین muscarinic; ACh; acetylcholine; B2M; beta-2-microglobuline; BDNF; brain derived neurotrophic factor; BSA; bovine serum albumin; cAMP; cyclic adenosine monophosphate; CarAT; carnitine acetyltransferase; ChAT; choline acetyltransferase; CO2; carbon dioxide; CT; cycle t
Keywords: گیرنده استیل کولین muscarinic; 7NI; 7-Nitroindazole; AB; angular bundle; AD; after discharge; AED; antiepileptic drugs; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; ANOVA; analysis of variance; CBr; cannabinoid receptors; DG; den
Keywords: گیرنده استیل کولین muscarinic; Caries susceptibility; Saliva flow; Muscarinic acetylcholine receptor; Acinar cell; Enamel hardness
Keywords: گیرنده استیل کولین muscarinic; Aβ; amyloid beta; ACh; acetylcholine; AChE; acetylcholinesterase; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BChE; butyrylcholinesterase; Iso-OMPA; tetraisopropyl pyrophosphamide; mAChR; muscarinic acetylcholine receptor; MM
Keywords: گیرنده استیل کولین muscarinic; ANOVA; analysis of variance; BESA; brain electric source analysis; Change-N1m; change-related auditory N1m; EEG; electroencephalography; fMRI; functional magnetic resonance imaging; MEG; magnetoencephalography; mAChR; muscarinic acetylcholine receptor; nA
Keywords: گیرنده استیل کولین muscarinic; M1; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); CNS penetration; Structure–activity relationship (SAR)
The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core
Keywords: گیرنده استیل کولین muscarinic; M1; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-Activity Relationship (SAR);
Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects
Keywords: گیرنده استیل کولین muscarinic; ACh; acetylcholine; ChE; cholinesterase; GPCR; G-protein-coupled receptors; mAChR; muscarinic acetylcholine receptor; OP; organophosphate; TA; mixture of trimedoxime bromide and atropine; CIE; clathrin-independent endocytosis; CDE; clathrin-dependent endo
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning
Keywords: گیرنده استیل کولین muscarinic; AChE; acetylcholinesterase; ACh; acetylcholine; BP; bispyridinium; CNS; central nervous system; 7α-nAChRs; human α7-nicotinic acetylcholine receptor(s); mAChR; muscarinic acetylcholine receptor; nAChRs; nicotinic acetylcholine receptor(s); OP; organopho
Physiological roles of CNS muscarinic receptors gained from knockout mice
Keywords: گیرنده استیل کولین muscarinic; Cholinergic; Muscarinic; Mice; Knockout; Knock-out; Null mutation; CIN; cholinergic interneuron; CAMKIIα; Ca2+/calmodulin-dependent protein kinase IIα; EPSP; excitatory postsynaptic potentials; HPA; hypothalamic-pituitary-adrenocortical; MAPK; mitogen-a
Highly specific detection of muscarinic M3 receptor, G protein interaction and intracellular trafficking in human detrusor using Proximity Ligation Assay (PLA)
Keywords: گیرنده استیل کولین muscarinic; BPS/IC; bladder pain syndrome/interstitial cystitis; CCV; clathrin-coated vesicles; CLSM; confocal laserscanning microscopy; EE; early endosome; FFPE; omalin- fixed paraffin-embedded; GP; G proteins; IF; immunofluorescence; IHC; immunohistochemistry; LE;
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Evidence for an autoimmune disease
Keywords: گیرنده استیل کولین muscarinic; AdR; adrenergic receptor; BAFF; B-lymphocyte activating factor; dUTPase; deoxyuridine 5â²-triphosphate nucleotidohydrolase; EBV; Epstein-Barr virus; FM; fibromyalgia; 5-HT; 5-hydroxytryptanime; HHV; human herpes virus; IFNγ; interferon gamma; KIR; kille
In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers
Keywords: گیرنده استیل کولین muscarinic; CNS; central nervous system; mAChR; muscarinic acetylcholine receptor; MB327; 1,1â²-(propane-1,3-diyl)bis(4-tert-butylpyridinium) di(iodide); nAChR; nicotinic acetylcholine receptor; NMG; N-methylglucamine; OPC(s); organophosphorus compound(s); PAM(s); p
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154
Keywords: گیرنده استیل کولین muscarinic; Positive allosteric modulator; VU0467154; Antipsychotic-like activity; Cognitive enhancement; M4 muscarinic acetylcholine receptor; MK-801; mAChR; muscarinic acetylcholine receptor; PAM; positive allosteric modulator; NMDAR; N-methyl-d-aspartate subtype o
Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor
Keywords: گیرنده استیل کولین muscarinic; AChE; acetylcholinesterase; CE; collision energy; CXP; collision cell exit potential; DP; declustering potential; EP; entrance potential; ESI; electrospray ionization; FDA; Food and Drug Administration; FIA; flow injection analysis; HI-6; 1-{[(4-carbamoyl
Muscarinic receptor oligomerization
Keywords: گیرنده استیل کولین muscarinic; Muscarinic acetylcholine receptor; Quaternary structure; Dimerization; Oligomerization; Ligand regulation; BRET; bioluminescence resonance energy transfer; CNO; clozapine-N-oxide; EL; extracellular loop; FCS; fluorescence correlation spectroscopy; FRET; f
The 5-HT3 receptor antagonist ondansetron potentiates the effects of the acetylcholinesterase inhibitor donepezil on neuronal network oscillations in the rat dorsal hippocampus
Keywords: گیرنده استیل کولین muscarinic; 5-HT3 receptor; Acetylcholinesterase inhibitor; Ondansetron; Donepezil; Neuronal oscillations; Alzheimer's disease; 5-HT; 5-hydroxytryptamine (serotonin); 5-HT3receptor; 5-hydroxytryptamine 3 receptor; 5-HT6receptor; 5-5-hydroxytryptamine 6 receptor; Aβ;
Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor
Keywords: گیرنده استیل کولین muscarinic; ACh; acetylcholine; mAChR; muscarinic acetylcholine receptor; GPCR; G protein-coupled receptor; AD; Alzheimer's disease; PAM; positive allosteric modulator; NAM; negative allosteric modulator; TM; transmembrane domain; ECL; extracellular loop; CHO; Chin
Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?
Keywords: گیرنده استیل کولین muscarinic; 2C-B; 2,5-Dimethoxy-4-bromophenethylamine; 4-FA; 4-Fluoroamphetamine; 4-MEC; 4-Methylethcathinone; 4-MMC; 4-Methylmethcathinone, a.k.a. mephedrone; 5-APB; 5-(2-Aminopropyl)benzofuran; 6-APB; 6-(2-Aminopropyl)benzofuran; 5-HT; Serotonin; 25B-NBOMe; 4-Bromo
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype
Keywords: گیرنده استیل کولین muscarinic; Pyrimidine; Muscarinic acetylcholine receptor; pan-Antagonist; DMPK; Structure-activity relationship (SAR);
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Keywords: گیرنده استیل کولین muscarinic; M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-activity relationship (SAR);
Localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment
Keywords: گیرنده استیل کولین muscarinic; Enteric nervous system; Muscarinic acetylcholine receptor; Stem cell compartment; Intestinal crypt; Paneth cell;
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides
Keywords: گیرنده استیل کولین muscarinic; M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Azetidine;
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists
Keywords: گیرنده استیل کولین muscarinic; Pyridazine; Muscarinic acetylcholine receptor; pan-Antagonist; DMPK; Structure-activity relationship (SAR);
Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer's disease
Keywords: گیرنده استیل کولین muscarinic; US-FDA; United States Food and Drugs Administration; AD; Alzheimer's disease; ACh; acetylcholine; PAM; positive allosteric modulator; mAChR; muscarinic acetylcholine receptor; AChE; acetylcholine esterase; LDC; lipid drug conjugate; NP; nanoparticle; GP
Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies
Keywords: گیرنده استیل کولین muscarinic; M5; Muscarinic acetylcholine receptor; Pharmacokinetics; CNS penetration; Structure-Activity Relationship (SAR);
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
Keywords: گیرنده استیل کولین muscarinic; M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Azetidine;
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core
Keywords: گیرنده استیل کولین muscarinic; M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Non-human primate (NHP); Structure-activity relationship (SAR);
Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats
Keywords: گیرنده استیل کولین muscarinic; BBB; blood-brain barrier; FS; fluorescein; mAChR; muscarinic acetylcholine receptor; SSN; superior salivatory nucleus; Cevimeline; Muscarinic acetylcholine receptor; Superior salivatory nucleus; Patch-clamp; Xerostomia;
Anhydroecgonine methyl ester, a cocaine pyrolysis product, may contribute to cocaine behavioral sensitization
Keywords: گیرنده استیل کولین muscarinic; Anhydroecgonine methyl ester; Crack cocaine; Dopamine; Muscarinic acetylcholine receptor; Behavioral sensitization;
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
Keywords: گیرنده استیل کولین muscarinic; M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Non-human primate (NHP); Structure-Activity Relationship (SAR);
Retinal changes in the Tg-SwDI mouse model of Alzheimer's disease
Keywords: گیرنده استیل کولین muscarinic; ACh; acetylcholine; AChR; acetylcholine receptor; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid beta; ChAT; choline acetyltransferase; GCL; ganglion cell layer; GFAP; glial fibrillary acidic protein; IHC; immunohistochemistry; iI
Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
Keywords: گیرنده استیل کولین muscarinic; ACh; acetylcholine; AP; action potential; APV; (2R)-amino-5-phosphonovaleric acid; DHβE; dihydro-β-erythroidine; DNQX; 6,7-dinitroquinoxaline-2,3-dione; EK; potassium equilibrium potential; GABA; γ-aminobutyric acid; HM; hypoglossal motoneuron; Ih; hyp
Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine
Keywords: گیرنده استیل کولین muscarinic; Enteric nervous system; Muscarinic acetylcholine receptor; Stem cell compartment; Intestinal crypt; Paneth cell;
Two opposite dose-dependent effects of diazinon on the motor activity of the rat ileum
Keywords: گیرنده استیل کولین muscarinic; Diazinon; Muscarinic acetylcholine receptor; Ileum; Ascaris suum;
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: گیرنده استیل کولین muscarinic; APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition
Keywords: گیرنده استیل کولین muscarinic; M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-Activity Relationship (SAR);
Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes
Keywords: گیرنده استیل کولین muscarinic; M5; Muscarinic acetylcholine receptor; Virtual screen; Structure–activity relationship (SAR)
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core
Keywords: گیرنده استیل کولین muscarinic; M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure–Activity Relationship (SAR)
Microinjection of acetylcholine into cerebellar fastigial nucleus induces blood depressor response in anesthetized rats
Keywords: گیرنده استیل کولین muscarinic; Acetylcholine; Muscarinic acetylcholine receptor; Nicotinic acetylcholine receptor; Blood pressure; Fastigial nucleus
CRAC channels are required for [Ca2 +]i oscillations and c-fos gene expression after muscarinic acetylcholine receptor activation in leukemic T cells
Keywords: گیرنده استیل کولین muscarinic; Acetylcholine; Muscarinic acetylcholine receptor; [Ca2 +]i oscillation; Ca2 + release-activated Ca2 + channels; T lymphocytes
The effect of coactivation of muscarinic and nicotinic acetylcholine receptors on LTD in the hippocampal CA1 network
Keywords: گیرنده استیل کولین muscarinic; Acetylcholine; Cholinergic; Interneuron; Muscarinic acetylcholine receptor; Nicotinic acetylcholine receptor; STDP
Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology
Keywords: گیرنده استیل کولین muscarinic; nAChR; nicotinic acetylcholine receptor; mAChR; muscarinic acetylcholine receptor; CNS; central nervous system; PNS; peripheral nervous system; OPC(s); organophosphorus compound(s); SURFE2R; surface electronic event reader; SSM; solid supported membrane(s
The cholinergic immune regulation mediated by a novel muscarinic acetylcholine receptor through TNF pathway in oyster Crassostrea gigas
Keywords: گیرنده استیل کولین muscarinic; Crassostrea gigas; Acetylcholine; Muscarinic acetylcholine receptor; TNF pathway; Immune regulation
Nicotinic acetylcholine receptor-mediated GABAergic inputs to cholinergic interneurons in the striosomes and the matrix compartments of the mouse striatum
Keywords: گیرنده استیل کولین muscarinic; Acetylcholine; Nicotinic; Cholinergic interneuron; Striosome; Matrix; ABT-418; 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; ACh; acetylcholine; AChE; acetylcholinesterase;
Carbachol dimers as homobivalent modulators of muscarinic receptors
Keywords: گیرنده استیل کولین muscarinic; Carbachol chloride (PubChem CID: 5831); Acetylcholine chloride (PubChem CID: 6060); Hexamethonium chloride (PubChem CID: 93550); Gallamine triethiodide (PubChem CID: 6172); Atropine sulfate (PubChem CID: 64663); Muscarinic acetylcholine receptor; Carbacho