Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 17, 1 September 2016, Pages 4282-4286

Michael R. Wood, Meredith J. Noetzel, James C. Tarr, Alice L. Rodriguez, Atin Lamsal, Sichen Chang, Jarrett J. Foster, Emery Smith, Peter Chase, Peter S. Hodder, Darren W. Engers, Colleen M. Niswender, Nicholas J. Brandon, Michael W. Wood,