Keywords: ساختار-فعالیت (SAR); Silyl chitosan; Guanidinyl chitosan; Trimethyl chitosan (TMC); Quaternary ammoniumyl chitosan; Antibacterial activity; Structure-activity relationship (SAR);
مقالات ISI ساختار-فعالیت (SAR) (ترجمه نشده)
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Keywords: ساختار-فعالیت (SAR); cell biology; drug interactions; distribution; structure-activity relationship (SAR); physicochemical properties; cell culture; log P; membrane transport; pharmacokinetics; partition coefficient;
Keywords: ساختار-فعالیت (SAR); Tree kernel; Support vector machine (SVM); Structure-activity relationship (SAR); Monte Carlo; Classification and regression tree (CART);
A simple and efficient synthesis of benzimidazoles containing piperazine or morpholine skeleton at C-6 position as glucosidase inhibitors with antioxidant activity
Keywords: ساختار-فعالیت (SAR); Benzimidazole; Microwave; α-Glucosidase; Antioxidant; Structure-activity relationship (SAR); Synthesis;
A structural investigation of FISLE-412, a peptidomimetic compound derived from saquinavir that targets lupus autoantibodies
Keywords: ساختار-فعالیت (SAR); Systemic lupus erythematosus (SLE); Autoimmune; Autoantibodies; Peptidomimetic; Anti-DNA antibody; DWEYS; Saquinavir; Structure-Activity Relationship (SAR);
Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist
Keywords: ساختار-فعالیت (SAR); EP4 receptor antagonist; Structure-activity relationship (SAR); Prostaglandin E2; Inflammation; Pain; Autoimmune diseases; Cancer; Clinical candidate;
The derivatives of Pulsatilla saponin A, a bioactive compound from Pulsatilla chinensis: Their synthesis, cytotoxicity, haemolytic toxicity and mechanism of action
Keywords: ساختار-فعالیت (SAR); Pulsatilla saponin A; Haemolytic activity; Cytotoxicity; Structure-activity relationship (SAR); Cell cycle arrest;
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
Keywords: ساختار-فعالیت (SAR); mGlu1; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-activity relationship (SAR);
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound
Keywords: ساختار-فعالیت (SAR); Choline transporter (CHT); ML352; Cognition; Novel object recognition (NOR); Structure-Activity Relationship (SAR);
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy
Keywords: ساختار-فعالیت (SAR); mGlu4; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Parkinson's disease; Structure-activity relationship (SAR);
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition
Keywords: ساختار-فعالیت (SAR); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-Activity Relationship (SAR);
Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles
Keywords: ساختار-فعالیت (SAR); PAR4; Platelet aggregation; Minimum pharmacophore; Structure-Activity Relationship (SAR);
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core
Keywords: ساختار-فعالیت (SAR); mGlu1; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-activity relationship (SAR);
Structure-activity relationship studies of QS11, a small molecule Wnt synergistic agonist
Keywords: ساختار-فعالیت (SAR); Wnt/β-catenin signaling; ADP-ribosylation factors; GTPase-activating proteins; QS11; Structure-activity relationship (SAR);
Synthesis and biological evaluation of spiro[cyclopropane-1,3â²-indolin]-2â²-ones as potential anticancer agents
Keywords: ساختار-فعالیت (SAR); Spirooxindoles; Cyclopropane; Anticancer agents; Structure-activity relationship (SAR);
Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists
Keywords: ساختار-فعالیت (SAR); Human P2Y6 receptor; Antagonist; UDP; Structure-activity relationship (SAR);
Evaluation of structural effects on 5-HT2A receptor antagonism by aporphines: Identification of a new aporphine with 5-HT2A antagonist activity
Keywords: ساختار-فعالیت (SAR); Aporphine; Nantenine; 5-HT2A; α1A; Antagonist; Structure-activity relationship (SAR);
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: Lead optimization
Keywords: ساختار-فعالیت (SAR); CRTh2 antagonist; Receptor residence time; Structure-activity relationship (SAR); Structure-kinetic relationship (SKR);
2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists
Keywords: ساختار-فعالیت (SAR); P2Y1 receptor antagonist; Antiplatelet; Urea mimetics; 2-Amino-1,3,4-thiadiazoles; Structure-activity relationship (SAR);
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I
Keywords: ساختار-فعالیت (SAR); CRTh2 antagonist; Receptor residence time; Structure-activity relationship (SAR); Structure-kinetic relationship (SKR);
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists
Keywords: ساختار-فعالیت (SAR); CRTh2 antagonist; Receptor residence time; Structure-activity relationship (SAR); Structure-kinetic relationship (SKR); Permeability; Prodrug;
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: The role of a hydrogen-bond acceptor in long receptor residence times
Keywords: ساختار-فعالیت (SAR); CRTh2 antagonist; Long residence time; Hydrogen bond acceptor; Structure-activity relationship (SAR); Structure-kinetic relationship (SKR);
Evaluation of anti-HCV activity and SAR study of (+)-lycoricidine through targeting of host heat-stress cognate 70 (Hsc70)
Keywords: ساختار-فعالیت (SAR); (+)-Lycoricidine; Heat-stress cognate 70 (Hsc70); Down-regulators; Structure-activity relationship (SAR); Anti-HCV activity;
Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors
Keywords: ساختار-فعالیت (SAR); HIV-1; Inhibitor; Triazolothienopyrimidine; Synthesis; Structure-activity relationship (SAR);
Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors
Keywords: ساختار-فعالیت (SAR); Atrial fibrillation (AF); Kv1.5; Indole derivatives; Structure-activity relationship (SAR);
Synthesis and structure-activity relationship studies of cytotoxic vinorelbine amide analogues
Keywords: ساختار-فعالیت (SAR); Vinorelbine; C-22 amide analogues; Tubulin inhibitor; Structure-activity relationship (SAR); Cytotoxicity;
Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogs
Keywords: ساختار-فعالیت (SAR); Ceric ammonium nitrate (CAN); Amide anhydrovinblastine analogs; Oxidative coupling; Structure-activity relationship (SAR); Cytotoxicity;
Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia
Keywords: ساختار-فعالیت (SAR); Lead optimization; Structure-activity relationship (SAR); Benzimidazole; H1-antihistamines; Insomnia; CNS penetration;
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
Keywords: ساختار-فعالیت (SAR); Pyrimidine analogues; Exchange proteins directly activated by cAMP (Epac); Antagonists; Structure-activity relationship (SAR);
Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death
Keywords: ساختار-فعالیت (SAR); Pictet-Spengler; RAS; Synthetic lethal; Structure-activity relationship (SAR); Non-apoptotic; Tetrahydro-β-carboline;
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders
Keywords: ساختار-فعالیت (SAR); Orexin receptor antagonist; G-Protein coupled receptor (GPCR); Central nervous system (CNS); Sleep disorders; Hypnotic agent; Conformational analysis; Structure-activity relationship (SAR);
Synthesis of novel inhibitors of β-glucuronidase based on benzothiazole skeleton and study of their binding affinity by molecular docking
Keywords: ساختار-فعالیت (SAR); Benzothiazole; β-Glucuronidase inhibition; Cytotoxicity; Glucuronosyl-O-bonds; Molecular docking; Structure-activity relationship (SAR); gold;
Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid
Keywords: ساختار-فعالیت (SAR); Human immunodeficiency virus type-1 (HIV-1); N-Terminal domain (NTD); C-Terminal domain (CTD); Capsid (CA); Peripheral blood mononuclear cell (PBMC); [(Sodium 3â²-(1-(phenylamino)-carbonyl)-3,4-tetrazolium-bis(4-methoxy-6-nitro) bezenesulfonic acid hydra
Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2â²,2â²-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents
Keywords: ساختار-فعالیت (SAR); 3â²R,4â²R-Di-O-(â)-camphanoyl-2â²,2â²-dimethyldihydropyrano[2,3-f]chromone (DCP) derivatives; HIV-1; Reverse transcriptase (RT); Structure-activity relationship (SAR);
Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors
Keywords: ساختار-فعالیت (SAR); Structure-activity relationship (SAR); Chymotrypsin-like (CT-L); Proteasome activity; Naphthoquinone pharmacophore; β5 and β6 subunits;
Development of fully functional proteins with novel glycosylation via enzymatic glycan trimming
Keywords: ساختار-فعالیت (SAR); glycoprotein; glycosylation; mass spectrometry; structure-activity relationship (SAR); circular dichroism; enzymes; protein structure;
High-field solution NMR spectroscopy as a tool for assessing protein interactions with small molecule ligands
Keywords: ساختار-فعالیت (SAR); protein binding; protein structure; proteins; structure-activity relationship (SAR); high-throughput technologies; drug interactions; drug design; NMR spectroscopy;
Synthesis, physicochemical and pharmacokinetic characterization of calcium uronates
Keywords: ساختار-فعالیت (SAR); Calcium complexes; d(+)-uronic acids; Spectroscopic and spectrometric methods; Thermal analysis; Hydration and coordination water; Structure-activity relationship (SAR); Pharmacokinetics;
Transition metal catalyzed oxidative functionalization of carbon-hydrogen bonds
Keywords: ساختار-فعالیت (SAR); Carbon-hydrogen bonds; Functionalization; Structure-activity relationship (SAR);