Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor 5 (mGlu5); Positive allosteric modulator (PAM); Cognition; Tetrahydrobenzotriazole;
مقالات ISI مدولاتور آلوزیستریک مثبت (PAM) (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M1; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); CNS penetration; Structure–activity relationship (SAR)
Keywords: مدولاتور آلوزیستریک مثبت (PAM); mGlu1; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure–Activity Relationship (SAR)
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor 4; Positive allosteric modulator (PAM); Pyrrole sulfonamide; Phenyl replacement; PK
The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M1; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-Activity Relationship (SAR);
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-activity relationship (SAR);
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Azetidine;
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Azetidine;
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Non-human primate (NHP); Structure-activity relationship (SAR);
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Non-human primate (NHP); Structure-Activity Relationship (SAR);
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
Keywords: مدولاتور آلوزیستریک مثبت (PAM); mGlu1; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-activity relationship (SAR);
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy
Keywords: مدولاتور آلوزیستریک مثبت (PAM); mGlu4; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Parkinson's disease; Structure-activity relationship (SAR);
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-Activity Relationship (SAR);
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core
Keywords: مدولاتور آلوزیستریک مثبت (PAM); M4; Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure–Activity Relationship (SAR)
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool
Keywords: مدولاتور آلوزیستریک مثبت (PAM); mGlu1; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure–Activity Relationship (SAR)
Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4
Keywords: مدولاتور آلوزیستریک مثبت (PAM); PET; Metabotropic glutamate receptor subtype 4 (mGlu4); Positive allosteric modulator (PAM)
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor; mGlu5; N-Methyl-d-aspartate (NMDA); Positive allosteric modulator (PAM); Schizophrenia;
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core
Keywords: مدولاتور آلوزیستریک مثبت (PAM); mGlu1; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Schizophrenia; Structure-activity relationship (SAR);
Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-Dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Muscarinic receptor 1; mAChR; M1; Positive allosteric modulator (PAM);
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor subtype 4 (mGlu4); Positive allosteric modulator (PAM); Positron emission tomography (PET); Affinity; Metabolic stability; Structure–affinity relationship (SAR)
Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound
Keywords: مدولاتور آلوزیستریک مثبت (PAM); mGlu5; Metabotropic glutamate receptor; Positive allosteric modulator (PAM); Pharmacokinetics; Schizophrenia
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Positive allosteric modulator (PAM); Metabotropic glutamate receptor 5 (mGlu5); Imidazopyrimidinone; Dihydroimidazopyrimidinone; Schizophrenia;
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor 5 (mGlu5); Positive allosteric modulator (PAM);
New screening strategy and analysis for identification of allosteric modulators for glucagon-like peptide-1 receptor using GLP-1 (9-36) amide
Keywords: مدولاتور آلوزیستریک مثبت (PAM); G-protein-coupled receptor (GPCR); β-arrestin; Receptor internalization; Glucagon-like peptide-1 (GLP-1); Positive allosteric modulator (PAM); High-throughput screening (HTS)GLP-1, glucagon-like peptide 1; GLP-1R, glucagon-like peptide 1 receptor; DM, dia
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor 5 (mGlu5); Positive allosteric modulator (PAM);
Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABAA receptors
Keywords: مدولاتور آلوزیستریک مثبت (PAM); iNOS; inducible NO-synthase; PAM; positive allosteric modulator; Ro15-1788; flumazenil, ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate; Allosteric modulation; GABAA receptor; Honokiol; Ion channel; Magnolol
Discovery of ML326: The first sub-micromolar, selective M5 PAM
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Muscarinic acetylcholine receptors; M5; Positive allosteric modulator (PAM); ML326;
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Muscarinic acetylcholine receptor 1; M1; Allosteric; Positive allosteric modulator (PAM); ML137; VU0448350;
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Muscarinic acetylcholine receptor 1; M1; Spirocyclic; Positive allosteric modulator (PAM); ML137; VU0413162
Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor 5; mGlu5; Positive allosteric modulator (PAM); Non-MPEP
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Metabotropic glutamate receptor 5 (mGlu5); Positive allosteric modulator (PAM); Non-MPEP;
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe
Keywords: مدولاتور آلوزیستریک مثبت (PAM); Muscarinic; Acetylcholine; Positive allosteric modulator (PAM); ML169; BQCA; Alzheimer’s disease; MLPCN