Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 6, 15 March 2015, Pages 1310-1317

María Luz Martín-Martín, José Manuel Bartolomé-Nebreda, Susana Conde-Ceide, Sergio A. Alonso de Diego, Silvia López, Carlos M. Martínez-Viturro, Han Min Tong, Hilde Lavreysen, Gregor J. Macdonald, Thomas Steckler, Claire Mackie, Thomas M. Bridges,