Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 27, Issue 2, 15 January 2017, Pages 171-175

Michael R. Wood, Meredith J. Noetzel, Michael S. Poslusney, Bruce J. Melancon, James C. Tarr, Atin Lamsal, Sichen Chang, Vincent B. Luscombe, Rebecca L. Weiner, Hyekyung P. Cho, Michael Bubser, Carrie K. Jones, Colleen M. Niswender, Michael W. Wood,