Keywords: انتخابی Isoform; Drug design; Isoform selectivity;
مقالات ISI انتخابی Isoform (ترجمه نشده)
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Keywords: انتخابی Isoform; Carbonic anhydrase inhibitors; Isoform selectivity; Zinc binding group; Primary sulfonamide; Aromatic sulfochlorination; Alternative binding mode;
Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor
Keywords: انتخابی Isoform; PI3Kδ inhibitor; Isoform selectivity; Pyrazolopyridine;
Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors
Keywords: انتخابی Isoform; PI3Kδinhibitor; Isoform selectivity; Pyrazolopyridine;
Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX
Keywords: انتخابی Isoform; 1,3,5-Triazine; Benzene sulfonamides; Amino acids; Carbonic anhydrase; Enzyme inhibition; Isoform selectivity;
Novel sulfonamide incorporating piperazine, aminoalcohol and 1,3,5-triazine structural motifs with carbonic anhydrase I, II and IX inhibitory action
Keywords: انتخابی Isoform; 1,3,5-Triazine; Benzene sulfonamides; Carbonic anhydrase; Enzyme inhibition; Isoform selectivity; RBTRACBIJHXJOW-UHFFFAOYSA-N; YBEIEFLSBAECJS-UHFFFAOYSA-N; CEJPWNPQLGPPAS-UHFFFAOYSA-N; IKVVCANHSURSQN-UHFFFAOYSA-N; UJOHKJMLFDCSCH-UHFFFAOYSA-N; OOTLZKHMVNUK
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline
Keywords: انتخابی Isoform; hMAO-B; Isoform selectivity; Fragment-based drug design; Structure activity relationship;
The structural requirements of histone deacetylase inhibitors: SAHA analogs modified at the C5 position display dual HDAC6/8 selectivity
Keywords: انتخابی Isoform; Histone deacetylase; HDAC inhibitors; Vorinostat; Isoform selectivity; HDAC6/8 selective inhibitor;
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads
Keywords: انتخابی Isoform; Carbonic anhydrase inhibitors; Multigram synthesis; Isoform selectivity; Picomolar inhibition; Primary sulfonamide; Ocular hypertension; X-ray crystallography;
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII
Keywords: انتخابی Isoform; Carbonic anhydrase; Inhibitor; Saccharin; Secondary/tertiary sulfonamide; Isoform selectivity;
Recent advances in JAK3 inhibition: Isoform selectivity by covalent cysteine targeting
Keywords: انتخابی Isoform; Janus kinase 3; Inflammation; Isoform selectivity; Chemical probes; Covalent inhibitors; Covalent-reversible inhibitors; CBRJPFGIXUFMTM-WDEREUQCSA-N; UJLAWZDWDVHWOW-YPMHNXCESA-N; HFNKQEVNSGCOJV-OAHLLOKOSA-N; CLGRAWDGLMENOD-UHFFFAOYSA-N; JSASWRWALCMOQP-UHF
Synthesis of a selective HDAC6 inhibitor active in neuroblasts
Keywords: انتخابی Isoform; Histone deacetylases; Isoform selectivity; HDAC6; PAMPA; Neuroblastoma cells;
Novel tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one: Design, synthesis, model and use as hMAO-B inhibitors
Keywords: انتخابی Isoform; hMAO; Isoform selectivity; Benzoxazepinone; Selective hMAO-B inhibitor; Anti-Parkinson
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors
Keywords: انتخابی Isoform; HATs, histone acetyl transferases; HDACs, histone deacetylases; SAR, structure activity relationship; SKR, structure kinetic relationship; T1/2, half-lifeHDAC inhibitors; Isoform selectivity; Kinetic selectivity; Target engagement; Acetylation
Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ
Keywords: انتخابی Isoform; PI3 kinase inhibitor; Isoform selectivity; Leukemia; Lymphoma;
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design
Keywords: انتخابی Isoform; Aurora kinases inhibitor; Indazole; Ligand efficiency; Isoform selectivity; Structure-activity relationship (SAR);
Probing the 'bipolar' nature of the carbonic anhydrase active site: Aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms
Keywords: انتخابی Isoform; Drug discovery; Carbonic anhydrase inhibitors; Isoform selectivity; Anti-glaucoma drugs; 1,3-oxadiazol-5-yl aromatics; Chemoselective sulfochlorination;
Evaluation of class I HDAC isoform selectivity of largazole analogues
Keywords: انتخابی Isoform; Largazole; HDAC inhibitor; Class I histone deacetylase; Isoform selectivity; Structure-activity relationship;
Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases
Keywords: انتخابی Isoform; HSP90 inhibitors; Isoform selectivity; Structure-based drug design; GRP94; TRAP1; Huntington's disease; Huntingtin;
Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII
Keywords: انتخابی Isoform; Carbonic anhydrase; 1,3,5-Triazine; Benzene sulfonamides; Isoform selectivity; Enzyme inhibition; Molecular docking
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform
Keywords: انتخابی Isoform; PI3-kinase; Isoform selectivity; Structure-based ligand design;
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
Keywords: انتخابی Isoform; PI3-Kinase inhibitors; Pharmacological tools; Aminothiazoles; Parallel synthesis; Isoform selectivity;
Inhibitory effect of the recombinant Phoneutria nigriventer Tx1 toxin on voltage-gated sodium channels
Keywords: انتخابی Isoform; Sodium channel; Sodium current; Spider toxin; Peptide toxin; Sodium channel inhibition; Isoform selectivity; PnTx1; Phoneutria nigriventer toxin 1; rPnTx1; recombinant PnTx1; KIIIA; μ-conotoxin KIIIA; GIIIA; μ-conotoxin GIIIA; SIIIA; μ-conotoxin SIIIA;
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity
Keywords: انتخابی Isoform; Histone deaceylases; HDAC inhibitors; Vorinostat; Isoform selectivity
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase
Keywords: انتخابی Isoform; Acetamidines; Isoform selectivity; 2-Methylimidazole derivatives; Nitric oxide synthase (NOS); NOS inhibitors
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Keywords: انتخابی Isoform; HDAC inhibitor; Isoform selectivity; HDAC3; Internal cavity; Biaryl; Spirocycle
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
Keywords: انتخابی Isoform; HDAC inhibitor; Isoform selectivity; HDAC3; Internal cavity; Biaryl
Insights into ligand selectivity in nitric oxide synthase isoforms: A molecular dynamics study
Keywords: انتخابی Isoform; Nitric oxide synthase; Molecular dynamics; Isoform selectivity; Water