کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7798102 1501095 2016 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thiosemicarbazone modification of 3-acetyl coumarin inhibits Aβ peptide aggregation and protect against Aβ-induced cytotoxicity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Thiosemicarbazone modification of 3-acetyl coumarin inhibits Aβ peptide aggregation and protect against Aβ-induced cytotoxicity
چکیده انگلیسی
Aggregation of amyloid-β peptide (Aβ) into amyloid plaques is essential event in Alzheimer's disease (AD) pathogenesis. Inhibition of Aβ aggregation is a promising avenue to explore as therapeutic treatment for AD. Our results indicate that 3-acetyl coumarin thiosemicarbazone inhibits Aβ(1-42) peptide aggregation up to 80% compared to the parent 3-acetyl coumarin which inhibits 49%. Further, 3-acetyl coumarin thiosemicarbazone provides neuroprotection against Aβ-induced cytotoxicity in SH-SY5Y cell line. These findings indicate that thiosemicarbazone modification renders 3-acetyl coumarin significant neuroprotective properties.117
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 121, 4 October 2016, Pages 803-809
نویسندگان
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