Keywords: پپتید بتا آمیلوئید; 4-HNE; 4-HydroxyNonenal; AD; Alzheimer's Disease; AICD; Amino-terminal APP Intra Cellular Domain; ApoE; Apolipoprotein E; APP; Amyloid Precursor Protein; ATP; Adenosine TriPhosphate; Aβ; Amyloid beta peptide; AβDP; Aβ-Degrading Proteases; CNS; Centra
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Keywords: پپتید بتا آمیلوئید; PS1 or PS2; presenilin-1 or presenilin-2; AD; Alzheimer's disease; APP; β-amyloid precursor protein; Aβ; amyloid beta peptide; IPTG; Isopropyl β-d-1-thiogalactopyranoside; PMSF; phenylmethylsulfonyl fluoride; FC14; Fos-choline-14; CHS; cholesteryl hemi
Keywords: پپتید بتا آمیلوئید; Multi-target drug design; Steered molecular dynamics; Alzheimer's disease; Amyloid beta peptide; β-secretase; PPARγ; LXRα;
Keywords: پپتید بتا آمیلوئید; Acetylcholinesterase inhibitors; Galantamine; Molecular docking; GoldScore; Indole; Amyloid beta peptide;
Keywords: پپتید بتا آمیلوئید; Virus capsid; Protein assembly; Assembly machine; Host factor; Prions; Neurodegenerative diseases; Allosteric sites; Catalysis; Protein conformational disease; Protein aggregation; Alzheimer's disease; Disrupted-in-schizophrenia 1; Amyloid beta peptide;
Keywords: پپتید بتا آمیلوئید; Graphene oxide; Amyloid beta peptide; Nanomaterials; Molecular dynamics simulation; Neurodegenerative disorders
Keywords: پپتید بتا آمیلوئید; LXR; liver X receptors; HDL; high-density lipoproteins; MD; molecular dynamics; NMR; nuclear magnetic resonance; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPC-d31; POPC deuterated at the sn-1 chain; chol; cholesterol; 7α-OH-chol; 7α-hydro
Keywords: پپتید بتا آمیلوئید; Aβ; amyloid beta peptide; APP; amyloid precursor protein; AD; Alzheimer's disease; DEXA; dual energy X-ray absorptiometry; BMD; bone mineral density; BMI; body mass index; OVX; ovariectomy; SHO; sham-operation; IHC; immunohistochemistry; OVCF; osteoporot
Keywords: پپتید بتا آمیلوئید; AC; adenylyl cyclases; AD; Alzheimer's disease; AJ; adherent junctions; AMPAR; alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor; APC; antigen presenting cell; APP; amyloid precursor protein; Aβ; amyloid beta peptide; CAM; cellular adhesion
Keywords: پپتید بتا آمیلوئید; AD; Alzheimer's disease; PAD; peptidyl arginine deiminase; GFAP; glial fibrillary acidic protein; PTCD2; penta-tricopeptide repeat domain-2; PBS; phosphate buffered saline; Aβ; amyloid beta peptide; P-tau; phosphorylated tau; HRP; horseradish peroxidase;
Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro
Keywords: پپتید بتا آمیلوئید; Amyloid beta peptides; Dipeptidyl peptidase IV; Enzyme-substrate interactions; Glutaminyl cyclase; MALDI-TOF mass spectrometry; Aβ; amyloid beta peptide; Aβ(1-40); amyloid beta peptide (1-40); Aβ(1-42); amyloid beta peptide (1-42); AD; Alzheimer's dise
Aluminum's preferential binding site in proteins: sidechain of amino acids versus backbone interactions
Keywords: پپتید بتا آمیلوئید; DFT; density functional theory; B3LYP; Becke, three-parameter, Lee-Yang-Parr DFT functional; MP2; Møller-Plesset perturbation theory; Ab; amyloid beta peptide; IEFPCM; integral equation formalism of polarizable continuum model; ATP; adenosine triphosph
Brain regional synchronous activity predicts tauopathy in 3ÃTgAD mice
Keywords: پپتید بتا آمیلوئید; Alzheimer's disease; Functional MRI; Hyperexcitability; Hippocampus; Tau; Amyloid beta peptide;
Research articleKnockdown of APPL mimics transgenic Aβ induced neurodegenerative phenotypes in Drosophila
Keywords: پپتید بتا آمیلوئید; Aβ; Amyloid beta peptide; AD; Alzheimer's disease; APP; Amyloid Precursor Protein; APPL; Amyloid Precursor Protein-Like; CPD; critical point drying; SEM; scanning electron microscopy; UAS; Upstream Activating Sequence; Drosophila; Alzheimer's disease; AP
Effect of ionic strength on the aggregation kinetics of the amidated amyloid beta peptide Aβ (1-40) in aqueous solutions
Keywords: پپتید بتا آمیلوئید; Amyloid beta peptide; Oligomer; Ionic strength; Light scattering; Linear polymer growth;
Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease
Keywords: پپتید بتا آمیلوئید; 5-HT4 receptor agonist; Alzheimer's disease; Memory impairments; Olfactory tubing maze; Transgenic mouse model; Pharmacotherapy; 5-HT4R; 5-Hydroxytryptamine type 4 receptor; Aβ; Amyloid beta peptide; AD; Alzheimer's Disease; ApoE; Apolipoprotein E; APP;
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate
Keywords: پپتید بتا آمیلوئید; SVCT; sodium-dependent vitamin C transporter; APP; amyloid precursor protein; PSEN1; presenilin 1; ASC; ascorbate; ROS; reactive oxygen species; Aβ; amyloid beta peptide; TMRE; tetramethylrhodamine, ethyl ester; Alzheimer's disease; Mitochondria; Oxida
ReviewCollagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients
Keywords: پپتید بتا آمیلوئید; Aβ; amyloid beta peptide; AD; Alzheimer disease; ApoE; apolipoprotein E; BM; basement membrane; CLE-1; C. elegans collagen XV/XVIII orthologue; CNS; central nervous system; CS; chondroitin sulphate; CSF; cerebrospinal fluid; DUF; domain of unknown functi
Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against β-amyloid-induced alterations in red blood cells
Keywords: پپتید بتا آمیلوئید; Amyloid beta peptide; Caspase 3; PKC; Red blood cell; Metabolism; AChE; AlzheimerAbeta, Amyloid beta peptide (1–42); AD, Alzheimer's disease; CF, caffeine; AChE, Acetylcholinesterase; PKC, protein kinase C; eNOS, endothelial nitric oxide synthase; RBC, re
Small molecule NPT-440-1 inhibits ionic flux through Aβ1 -42 pores: Implications for Alzheimer's disease therapeutics
Keywords: پپتید بتا آمیلوئید; Alzheimer's disease; Amyloid beta peptide; Amyloid pore; Small molecule; Calcium; Bilayer electrophysiology; Atomic force microscopy;
Obestatin promotes proliferation and survival of adult hippocampal progenitors and reduces amyloid-β-induced toxicity
Keywords: پپتید بتا آمیلوئید; Obestatin; Hippocampal progenitors; Cell survival; PI3K/Akt; GSK-3β/β-catenin; Amyloid beta peptide; AHP; adult rat hippocampal progenitor cells; Aβ; amyloid-beta peptide; AD; Alzheimer's disease; BrdU; 5-bromo-2-deoxyuridine; BSA; bovine serum albumin
Protective effect of recombinant soluble neprilysin against β-amyloid induced neurotoxicity
Keywords: پپتید بتا آمیلوئید; Recombinant soluble neprilysin; Protein theraphy; Amyloid beta peptide; Neurotoxicity; Alzheimer's disease;
Thiosemicarbazone modification of 3-acetyl coumarin inhibits Aβ peptide aggregation and protect against Aβ-induced cytotoxicity
Keywords: پپتید بتا آمیلوئید; Alzheimer's disease; Amyloid beta peptide; Aggregation; Thiosemicarbazone; Fluorescence; Cytotoxicity;
GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells
Keywords: پپتید بتا آمیلوئید; Aβ; amyloid beta peptide; AD; Alzheimer's disease; ADAM; A disintegrin and metalloproteinase; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; beta-secretase; CHO; Chinese hamster ovary; CTF; C-terminal fragment; DN; dominant negative; FA
Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice
Keywords: پپتید بتا آمیلوئید; AD; Alzheimer's disease; apoE; apoliporpotein E; apoE TR mice; human apoE3- and apoE4-targeted replacement mice; APP; amyloid precursor protein; Aβ; amyloid beta peptide; BDNF; Brain-derived Neurotrophic Factor; DDCt; Delta-Delta Ct; EDTA; ethylenedi
Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e PrÃncipe
Keywords: پپتید بتا آمیلوئید; Aβ; amyloid beta peptide; AD; Alzheimer׳s disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; BBB; blood-brain barrier; CLogP; lipophilicity; CNS; Central nervous system; DMEM; Dulbecco׳s modified Eagle׳s medium; ESI; Electrospray
Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell
Keywords: پپتید بتا آمیلوئید; AD; Alzheimer's disease; mtDNA; Mitochondrial DNA; DLP1; Dynamin-like protein; Mfn2; Mitofusin 2; ERK; Extracellular signal-regulated kinase; Aβ; Amyloid beta peptide; CcO; Cytochrome c oxidase; ROS; Reactive oxygen species; PD; Parkinson disease; HD; Hu
Structure-activity relationships of small molecule inhibitors of RAGE-Aβ binding
Keywords: پپتید بتا آمیلوئید; Receptor for advanced glycation endproducts; Amyloid beta peptide; Focused library; Alzheimer's disease;
Knockout of Toll-like receptor 2 attenuates Aβ25-35-induced neurotoxicity in organotypic hippocampal slice cultures
Keywords: پپتید بتا آمیلوئید; TLR2; Toll-like receptor 2; TLR2-KO; Toll-like receptor 2-knockout; WT; wild-type; PI; propidium iodide; AD; Alzheimer's disease; Aβ; amyloid beta peptide; OHSCs; organotypic hippocampal slice cultures; Toll-like receptor 2 (TLR2); Aβ25-35-induced n
Surface induced collapse of Aβ1-42 with the F19A replacement following adsorption on a single walled carbon nanotube
Keywords: پپتید بتا آمیلوئید; Amyloid beta peptide; Carbon nanotube; Molecular dynamics simulation; Adsorption; Surface induced collapse; Lateral mobility;
A data treatment method for detecting fluorescence anisotropy peaks in capillary electropherograms
Keywords: پپتید بتا آمیلوئید; Fluorescence anisotropy; Data treatment; Capillary electrophoresis; Amyloid beta peptide;
Synaptic localization of acylpeptide hydrolase in adult rat telencephalon
Keywords: پپتید بتا آمیلوئید; Acylpeptide hydrolase; Excitatory synapse; Synaptic localization; Rat hippocampus; ACPH; acylpeptide hydrolase; Aβ; amyloid beta peptide; AChE; acetylcholinesterase; AANA; acetyl-alanyl-p-nitroanilide; DTNB; dithiobisnitrobenzoate; DDVP; 2,2-dichloroviny
Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers
Keywords: پپتید بتا آمیلوئید; Fab; Antigen-binding fragment; PDB; Protein Data Bank; AD; Alzheimer's disease; M204; Monoclonal antibody 204; PFOs; Prefibrillar oligomers; Aβ; Amyloid beta peptide; FOs; Fibrillar oligomers; APFs; Annular protofibrils; IgG; Immunoglobulin G; (HEK293) c
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperNeuregulin-1 protects against neurotoxicities induced by Swedish amyloid precursor protein via the ErbB4 receptor
Keywords: پپتید بتا آمیلوئید; Alzheimer's disease; neuregulin1; ErbB4; Swedish mutation of amyloid precursor protein; amyloid beta peptide; AD; Alzheimer's disease; Aβ; amyloid beta peptide; BACE1; β-site APP-cleaving enzyme 1; DCFH-DA; 2,7-dichlorofluorescein diacetate; FAD; early-
Neuregulin-1 prevents amyloid β-induced impairment of long-term potentiation in hippocampal slices via ErbB4
Keywords: پپتید بتا آمیلوئید; Alzheimer's disease; Amyloid beta peptide; Hippocampus; Long-term potentiation; Neuregulin; ErbB4
Analysis of Aβ (1-40) and Aβ (1-42) monomer and fibrils by capillary electrophoresis
Keywords: پپتید بتا آمیلوئید; Capillary electrophoresis; UV absorbance; Amyloid beta peptide; Protein aggregation; Mass spectrometry
Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers
Keywords: پپتید بتا آمیلوئید; Amyloid beta peptide; Trehalose; Monolayer; Alzheimer's disease; Membrane;
Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease
Keywords: پپتید بتا آمیلوئید; PAI-1; Amyloid beta peptide; Plasmin; Alzheimer's disease; Aging; Knockout
Beyond the signaling effect role of amyloid-β42 on the processing of APP, and its clinical implications
Keywords: پپتید بتا آمیلوئید; Aging; Alzheimer's disease; Amyloid beta peptide; Clinical trial; Dementia; Drug discovery; Gene regulation; Molecular pharmacology; Signaling; Transcription factor; Treatment
Docosahexaenoic acid supplementation of primary rat hippocampal neurons attenuates the neurotoxicity induced by aggregated amyloid beta protein42 and up-regulates cytoskeletal protein expression
Keywords: پپتید بتا آمیلوئید; Alzheimer's disease; Docosahexaenoic acid; Cytoskeleton; Amyloid beta peptide; Hippocampus; Neuron protection
Circulating neprilysin clears brain amyloid
Keywords: پپتید بتا آمیلوئید; Neprilysin; Alzheimer's disease; Gene therapy; Adeno-associated virus; Amyloid beta peptide
Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration
Keywords: پپتید بتا آمیلوئید; Aging; Amyloid beta peptide; Apoptosis; Ceramide; Cerebrovascular disease; Endothelial cells; Mitochondria; Stroke
Co-localization of PRiMA with acetylcholinesterase in cholinergic neurons of rat brain: An immunocytochemical study
Keywords: پپتید بتا آمیلوئید; 3n; oculomotor nucleus; Aβ; amyloid beta peptide; AChE; acetylcholinesterase; ChAT; choline acetyltransferase; EM; electron microscope; ER; endoplasmic reticulum; GAD67; glutamic acid decarboxylase 67; LB; lamellar body; MS/DB; medial septum diagonal ban
Could a dysfunction of ferritin be a determinant factor in the aetiology of some neurodegenerative diseases?
Keywords: پپتید بتا آمیلوئید; Aβ; Amyloid beta peptide; AD; Alzheimer's disease; ATEM; Analytical transmission electron microscopy; CAT; Computed axial tomography; ED; Electron diffraction; EELS; Electron energy loss spectrometry; END; Electron nanodiffraction; EXAFS; Extended X-ray
TrkA pathway activation induced by amyloid-beta (Abeta)
Keywords: پپتید بتا آمیلوئید; Alzheimer; Amyloid beta peptide; NGF; TrkA; AKT; GSK-3β
Reduced amyloidogenic processing of the amyloid β-protein precursor by the small-molecule Differentiation Inducing Factor-1
Keywords: پپتید بتا آمیلوئید; Aβ; amyloid beta peptide; AD; Alzheimer's disease; ALLN; Acetyl-l-Leucyl-l-Leucyl-l-Norleucinal; APP; amyloid-β protein precursor; APLP1; amyloid precursor-like protein 1; APLP2; amyloid precursor-like protein 2; αCTF (C83); C-terminal fragment of APP
Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice
Keywords: پپتید بتا آمیلوئید; neuroinflammation; cRaf-1; amyloid beta peptide; IκBα; Alzheimer's disease; NexavarAD, Alzheimer's disease; APP, amyloid beta peptide precursor protein; Aβ, amyloid beta peptide; Cox-2, cyclooxygenase-2; iNOS, inducible nitric oxide synthase; LTP, long-te
Amyloid-β peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2
Keywords: پپتید بتا آمیلوئید; Phospholipase; Alzheimer; NADPH oxidase; Amyloid beta peptide; Astrocytes
In vitro and in vivo degradation of Aβ peptide by peptidases coupled to erythrocytes
Keywords: پپتید بتا آمیلوئید; Peptidases; Amyloid beta peptide; Peripheral degradation; Erythrocytes
Copper complexing decreases the ability of amyloid beta peptide to cross the BBB and enter brain parenchyma
Keywords: پپتید بتا آمیلوئید; Alzheimer's disease; Amyloid beta peptide; Copper; BBB