Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers

►Aβ insertion into DPPG monolayers in water exhibits a temperature dependent lag time. ►The presence of trehalose eliminates the lag time before Aβ insertion starts. ►More peptide is inserted into the monolayer in the water subphase. ►Trehalose reduces the conformational change that Aβ undergoes when it inserts. ►Aβ inserts parallel to the monolayer in water and with a 50° angle in the trehalose subphase.