Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands

New 1-(4-(aryl(methyl)amino)butyl)-heterocyclic derivatives were designed and synthesized in order to evaluate their affinity towards σ receptors by radioligand binding assays. Moreover, in order to investigate their cytotoxic activity, a functional assay was performed. Some of these derivatives showed a remarkable affinity and selectivity towards σ1 receptors and an interesting cytotoxic profile.96