Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation

A series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins (2-15) was investigated on 5-HT7, 5-HT1A and D2 receptors affinity. VS/docking, synthesis, radioligand binding and functional assays as well as metabolic stability studies were performed.312