Keywords: Aripiprazole; Risperidone; Olanzapine; Cannabinoid receptors; Adolescent rat; 5-HT; serotonin; ADHD; attention deficit hyperactivity disorder; ANOVA; analysis of variance; APDs; antipsychotic drugs; BSA; bovine serum albumin; cAMP; cyclic adenosine monoph
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Keywords: Dopamine; Serotonin; Obesity; Neuroimaging; Humans; 5-HT1A,B; serotonin 1A and 1B receptor; 5-HT2A; serotonin 2A receptor; 5-HT2C; serotonin 2C receptor; 5-HT4; serotonin 4 receptor; Bmax; receptor or transporter availability; BMI; body mass index; BP; bi
Keywords: 5-HT; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AC; anterior cingulate; ADHD; attention deficit hyperactivity disorders; AES; Apathy Evaluation Scale; AI; Apathy Inventory; AS; Apathy Scale; BG; basal ganglia; D2R/D3R; D2/D3 dopamine receptors; D2R;
Keywords: ASPS; advanced sleep phase syndrome; AUD; alcohol use disorder; BDZ; benzodiazepine; CK1; casein kinase 1; CD; circadian desynchrony; CRSDs; circadian rhythm sleep disorders; DSPS; delayed sleep phase disorder; DA; dopamine; DARPP32; dopamine- and cAMP-re
Keywords: ANOVA; analysis of variance; CET; cue exposure therapy; CS; conditioned stimulus; D2R; dopamine 2 receptor; EXT; extinction; FR; fixed ratio; REM; rapid eye movement; RM; repeated measures; Incubation of craving; Cocaine; Adolescent; Self-administration;
Keywords: AD; Alzheimer's disease; cAMP; cyclic adenosine monophosphate; CB1R; Cannabinoid receptor 1; CNS; central nervous system; co-IP; co-immunoprecipitation; Cy3; cyanine 3; D2R; dopamine receptor 2; ERK1/2; extracellular signal-regulated kinase 1/2; FITC; f
Keywords: D2R; dopamine receptor; cAMP; cyclic adenosine monophosphate; PKA; protein kinase A; DARPP-32; dopamine and cAMP-regulated phosphoprotein; PP1; protein phosphatase 1; MEK; mitogen-activated protein kinase/ERK kinase; ERK; extracellular-signal regulated ki
Keywords: DENV; dengue virus; DF; dengue fever; DHF; dengue hemorrhagic fever; DSS; dengue shock syndrome; ADE; antibody-dependent enhancement; HCV; hepatitis C virus; HTS; high-throughput screening; TNFα; tumor necrosis factor α; IFN; interferon; MCP-1; monocyte
Keywords: EEG; Encephalitis; NMDAR; Herpes; FIRES; DRE; Autoimmune; ADEM; acute disseminated encephalomyelitis; CNS; central nervous system; CSF; cerebrospinal fluid; D2R; dopamine-2 receptor; DRE; drug resistant epilepsy; EEG; electroencephalogram; HSE; Herpes sim
Keywords: CNO; Clozapine-N-Oxide; D2R; dopamine D2 receptor; dlPFC; dorsolateral PFC; DTI; diffusion tensor imaging; fMRI; functional MRI; GPe; globus pallidus externa; GPi; globus pallidus interna; MD; medidorsal thalamus; MIA; maternal immune activation; MRI; mag
Keywords: ID; iron deficiency, iron deficient; DA; dopamine; DAT; dopamine transporter; PND; postnatal day; D1R; dopamine type-1 receptor; D2R; dopamine type-2 receptor; NAc; nucleus accumbens; VTA; ventral tegmental area; iv; intravenous; FR; fixed ratio; PR; prog
Keywords: ACC; Anterior Cingulate Cortex; BLA; Baso-Lateral Amygdala; DLS; Dorsolateral Striatum; DMS; Dorsomedial; IL; Infra-Limbic Cortex; lOFC; Lateral Orbitofrontal Cortex; MD; mediodorsal thalamus; mOFC; Medial Orbitofrontal Cortex; mPFC; medial prefrontal cor
Keywords: DA; dopamine; PD; Parkinson's disease; ADHD; attention-deficit hyperactivity disorder; ASD; autism spectrum disorders; SRY; sex-determining region on the Y chromosome; SNc; substantia nigra pars compacta; SNr; substantia nigra pars reticulata; VTA; ventra
Keywords: 6-OHDA; 6-hydroxyldopamine; D1R; dopamine D1 receptor; D2R; dopamine D2 receptor; DCX; doublecortin; DG; dentate gyrus; HD; Huntington's disease; L-DOPA; 3,4-dihydroxy-l-phenylalanine; micro-PET; micro-positron emission tomography; MFB; medial forebrain b
Keywords: Anhedonia; Depression; Learning and memory; Palliative care in Parkinson's disease; D5r; D3r; D2r;
Keywords: ACC; anterior cingulate cortex; AMPA; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; One-Way Analysis of Variance; CAb; core of the nucleus accumbens; CREB; Ca++ Responsive Element Binding Protein; D1R; dopamine D1 receptor; D2R; dopamine D
Keywords: KI; knock-in; KO; knockout; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; DOPA; dihydroxyphenylalanine; DRD; dopa-responsive dystonia; GABA; γ-aminobutyric acid; 5-HT; serotonin; HVA; homovanillic acid; TH; tyrosine hydroxylase; D2R; dopami
Keywords: CO; competitive inhibitor; [D]; molar concentration of antipsychotics in the extracellular fluid; DAT; dopamine transporter; D2R; dopamine D2 receptor; D2H; high-affinity D2R; D2L; low-affinity D2R; EC50; half-maximal effective concentration; Kd; dissocia
Prenatal vitamin D deficiency does not exacerbate behavioural impairments associated with prenatal ethanol exposure in juvenile male mice
Keywords: Juvenile mouse behaviour; Foetal alcohol exposure; Vitamin D deficiency; 25(OH)D; 25-hydroxyvitamin D (calcidiol); Aadc; aromatic L-amino acid decarboxylase; ADHD; attention deficit hyperactivity disorder; ASD; Autism spectrum disorder; COMT; comethyl tra
Ventral tegmental area D2 receptor knockdown enhances choice impulsivity in a delay-discounting task in rats
Keywords: AAV; adeno-associated virus; AUC; area under the curve; BACT; beta-actin mRNA; CMV; cytomegalovirus; D2R; dopamine D2 receptor, D1R, dopamine D1 receptor, DA, dopamine, DRD2, D2R mRNA, DS, dorsal striatum; EGFP; enhanced green fluorescent protein; ENO2; E
Manganese toxicity is targeting an early step in the dopamine signal transduction pathway that controls lateral cilia activity in the bivalve mollusc Crassostrea virginica
Keywords: Adenylyl cyclase; Gill cilia; Dopamine; D2R; Manganese; Oyster;
The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance
Keywords: Adipose tissue; Antipsychotics; Fatty acid; Fatty liver; Insulin resistance; Sulpiride; ACC; acetyl-CoA carboxylase; Adipo-IR; adipose tissue insulin resistance; AUC; area under the curve; ChREBP; carbohydrate-response element-binding protein; D2R; dopami
Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
Keywords: Parkinson's disease; L-DOPA-Induced dyskinesia; Abnormal involuntary movements; D1R-D3R interactions; DA; Dopamine; DOPAC; Dihydroxyphenylacetic acid; PD; Parkinson's disease; LID; L-DOPA-Induced Dyskinesia; D1R; Dopamine D1 Receptor; D2R; Dopamine D2 Rec
Distinctive Changes of L-Type Calcium Channels and Dopamine Receptors in the Dorsomedial and Dorsolateral Striatum after the Expression of Habitual Cocaine-Seeking Behavior in Rats
Keywords: CREB; cAMP-response element binding protein; D1R; D1 receptors; D2R; D2 receptors; DA; dopamine; DLS; dorsolateral striatum; DMS; dorsomedial striatum; DS; dorsal striatum; FI; fixed interval; LTCCs; L-type calcium channels; NAc; nucleus accumbens; RI; ra
Effect of in vivo exposure to ambient fine particles (PM2.5) on the density of dopamine D2-like receptors and dopamine-induced [35S]-GTPγS binding in rat prefrontal cortex and striatum membranes
Keywords: D2R; dopamine D2 receptor; MSN; striatal medium-sized spiny neuron; PFC; prefrontal cortex; PM2.5; fine particles; Fine particles; PM2.5; Prefrontal cortex; Striatum; D2 receptor; Dopamine;
Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain
Keywords: ASD; autism spectrum disorder; ChAT; choline acetyltransferase; D1R; D1 receptor; D2R; D2 receptor; Foxp; Forkhead-box p; LGE; lateral ganglionic eminence; MGE; medial ganglionic eminence; nNOS; neuronal nitric oxide synthase; PBS; phosphate-buffered sali
Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum
Keywords: A2AR; Adenosine A2A receptor; cAMP; Cyclic adenosine monophosphate; D1R; Dopamine D1 receptor; D2R; Dopamine D2 receptor; dMSNs; Direct pathway striatal medium-sized spiny neurons; GABA; γ-Aminobutyric acid; GPCRs; G-protein coupled receptors; H2R; Hista
Impact of G protein-coupled receptor heteromers in endocrine systems
Keywords: GPCR; Dimer; Oligomer; Signaling; Heteromer; α1BR; α1B adrenergic receptors; AT1R; Angiotensin 1 receptor; BRET; Bioluminescence resonance energy transfer; B2R; Bradykinin 2 receptor; CRH; Corticotrophin releasing hormone; D2R; Dopamine D2 receptor; FRE
Research PaperTraumatic brain injuries during development disrupt dopaminergic signaling
Keywords: D2R; dopamine D2 receptor; DAT; dopamine transporter; mTBI; mild traumatic brain injury; TH; tyrosine hydroxylase; UCN; urocortin; VTA; ventral tegmental area; Traumatic brain injury; Development; Alcohol; Dopamine; Hypodopaminergia;
Paeoniflorin and liquiritin, two major constituents in Chinese herbal formulas used to treat hyperprolactinemia-associated disorders, inhibits prolactin secretion in prolactinoma cells by different mechanisms
Keywords: D2R; dopamine D2 receptors; MCP; metoclopramide; TGF; transforming growth factor; TNF; tumor necrosis factor; YRTJ; Yiru Tiaojing; Dopamine D2 receptor; Hyperprolactinemia; Paeoniflorin;
Cocaine modulates allosteric D2-Ï1 receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum
Keywords: CREB; cAMP Response Element-Binding protein; CNS; central nervous system; D2R; D2 receptor; DA; dopamine; DAT; dopamine transporter; HEK293T; Human Embryonic Kidney cells 293; NER; net extra-outflow; Ï1Rs; Ï1 receptors; Cav 1.3; voltage dependent calciu
Altered adenosine 2A and dopamine D2 receptor availability in the 6-hydroxydopamine-treated rats with and without levodopa-induced dyskinesia
Keywords: A2AR; Adenosine 2A receptor; AIM; abnormal involuntary movement; ANOVA; analysis of variance; BPND; non-displaceable binding potential; CNS; central nervous system; D2R; dopamine type 2 receptor; L-DOPA; levodopa; LID; levodopa-induced dyskinesia; MRTM; I
Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats
Keywords: AAAD; aromatic amino acid decarboxylase; AQC; 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate; ASCA; ANOVA Simultaneous Component Analysis; BCAA; branched chain amino acids; brainECF; brain extracellular fluid; CNS; central nervous system; D2R; dopamine D
Research PaperStrength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; ChI; cholinergic interneurons; D2R; dopamine D2 receptors; mAChR; muscarinic receptors; Oxo; oxotremorine; Quin; quinpirole; Neo; neostigmine; TorA; torsinA; Dystonia; DYT1; Dorsal striatum; Cholinergic inte
Disruption of dopamine D1/D2 receptor complex is involved in the function of haloperidol in cardiac H9c2 cells
Keywords: cAMP; 3â²5â²-cyclic adenosine monophosphate; D1R; dopamine D1 receptor; D2R; dopamine D2 receptor; DBP; diastolic blood pressure; Hal; haloperidol; HR; heart rate; IP3; inositol 1,4,5-trisphosphate; IP3R1; IP3 receptor type 1; Me; melperone hydrochlorid
Chronic exposure to dopamine agonists affects the integrity of striatal D2 receptors in Parkinson's patients
Keywords: AIMS; Abnormal Involuntary Movement Scale; BDI-II; Beck Depression Inventory; BPND; non-displaceable binding potential; D2R; dopamine receptor type-2; H&Y; Hoehn and Yahr staging; LED; levodopa-equivalent-dose; MMSE; Mini-Mental State Examination; MRI; ma
Bradykinin B2 and dopamine D2 receptors form a functional dimer
Keywords: BK; bradykinin; B2R; bradykinin B2 receptor; D2R; dopamine D2 receptor; FBS; fetal bovine serum; GPCRs; G protein-coupled receptors; HOE 140; icatibant; PCC; Pearson's correlation coefficient; SUM; sumanirole; Bradykinin 2 receptor; Ca2+-dependent signali
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Keywords: 5-HT; 5-hydroxytryptamine; 7,8-DHF; 7,8-dihydroxyflavone; ACh; acetylcholine; AD; adenosine; ADL; activities of daily living; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; 5â²AMP-activated protein kinase; BDNF; brain-derived neurotro
Age-related changes in binding of the D2/3 receptor radioligand [11C](+)PHNO in healthy volunteers
Keywords: Dopamine; Aging; D2R; D3R; PET imaging; [11C](+)PHNO;
17β-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo
Keywords: AMPH; amphetamine; AP; anteroposterior; D2R; dopamine D2 receptor; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; DS; dorsal striatum; DV; dorsoventral; E2; 17β-estradiol; ER; estrogen receptor; GABA; γ-aminobutyric acid; GPER-1; G-protein-coupled
Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens
Keywords: Histamine; Dopamine; H3 receptor; Nucleus accumbens; Dopamine synthesis; Dopamine release; D2R; dopamine D2 receptor; DOPA; l-dihydroxyphenylalanine; GABA; γ-aminobutyric acid; H3R; histamine H3 receptor; MSNs; medium spiny neurons; RAMH; (R)(-)-α-methy
Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
Keywords: Anxiety; Fear; Amygdala; Dopamine D2 receptor; Oxytocin receptor; Receptor-receptor interactions; Raclopride; Oxytocin; Heteroreceptor complexes; AC; adenylyl cyclase; BLA; basolateral complex; ADAR; adenosine A receptor; CAS; castor transcription factor;
Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation
Keywords: Behavioral thrift; Dietary induced obesity; D2R; Reward deficiency; Running wheels; Voluntary exercise
Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation
Keywords: Hydantoins; Phenylpiperazines; Virtual screening; 5-HT7R; 5-HT1AR; D2R; 5-HT7R antagonists;
Histamine H3 receptor activation stimulates calcium mobilization in a subpopulation of rat striatal neurons in primary culture, but not in synaptosomes
Keywords: Histamine; H3 receptor; Striatum; Calcium mobilization; Primary culture; Synaptosomes; ACPD; (±)-trans 1-Amino-1,3-dicarboxycyclopentane; [Ca2+]i; intracellular concentration of Ca2+; CNS; Central Nervous System; D1R; dopamine D1 receptor; D2R; dopamine
Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases
Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer⿿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy
Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA
Keywords: cAMP; cyclic adenosine monophosphate; D2R; dopamine D2 receptor; ECL; enhanced chemiluminescence; ERK 1/2; extracellular signal-regulated kinase 1/2; GABA; γ-amino butyric-acid; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; HRP; horseradish peroxidas
Role of Drosophila calcium channel cacophony in dopaminergic neurodegeneration and neuroprotection
Keywords: cac; cacophony; DIV; days in vitro; DA; dopaminergic; D2R; dopamine type-2 receptor; DD2R; Drosophila dopamine type-2 receptor; EGTA; ethylene glycol tetraacetic acid; MPP+; 1-methyl-4-phenylpyridinium; PD; Parkinson's disease; ROS; reactive oxygen spec
Protein kinase C beta regulates the D2-Like dopamine autoreceptor
Keywords: Dopamine; Autoreceptor; Exocytosis; Quinpirole; Synaptosomes; DAT; dopamine transporter; D2R; D2-like dopamine receptor; D2 autoreceptor; D2-like dopamine autoreceptor; SNARE; Soluble NSF Attachment Protein Receptor; PKC; protein kinase C; KRB; Krebs-Ring
Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells
Keywords: Dopamine; Lung cancer; VEGF; Cabergoline; Angiogenesis; Dopamine D2 receptor agonists; D2R; dopamine D2 receptor; LLC1; Lewis lung carcinoma 1; NSCLC; non-small cell lung cancer; VEGF; vascular endothelial growth factor A; EGFR; epidermal growth factor re