کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627870 1406357 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Etiological associations and outcome predictors of acute electroencephalography in childhood encephalitis
ترجمه فارسی عنوان
انجمن های علمی و نتایج پیش بینی کننده الکتروانسفالوگرافی حاد در آنسفالیت دوران کودکی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- A non-reactive EEG background on early EEG predicts abnormal outcome in children with encephalitis.
- Seizures with shifting ictal focality predict drug resistant epilepsy in children with encephalitis.
- Children with NMDAR encephalitis have reactive early EEG background & demonstrate extreme spindles.

ObjectivesTo examine EEG features in a retrospective 13-year cohort of children with encephalitis.Methods354 EEGs from 119 patients during their admission were rated blind using a proforma with demonstrated inter-rater reliability (mean k = 0.78). Patients belonged to 12 etiological groups that could be grouped into infectious and infection-associated (n = 47), immune-mediated (n = 36) and unknown (n = 33). EEG features were analyzed between groups and for risk of abnormal Liverpool Outcome Score and drug resistant epilepsy (DRE) at last follow up.Results86% children had an abnormal first EEG and 89% had at least one abnormal EEG. 55% had an abnormal outcome, and 13% had DRE after median follow-up of 7.3 years (2.0-15.8 years). Reactive background on first EEGs (9/11, p = 0.04) and extreme spindles (4/11, p < 0.001) distinguished patients with anti-N-Methyl-d-Aspartate Receptor encephalitis. Non-reactive EEG background (48% first EEGs) predicted abnormal outcome (OR 3.8, p < 0.001). A shifting focal seizure pattern, seen in FIRES (4/5), anti-voltage gated potassium channel (2/3), Mycoplasma (1/10), other viral (1/10) and other unknown (1/28) encephalitis, was most predictive of DRE after multivariable analysis (OR 11.9, p < 0.001).ConclusionsNon-reactive EEG background and the presence of shifting focal seizures resembling migrating partial seizures of infancy are predictors of abnormal outcome and DRE respectively in childhood encephalitis.SignificanceEEG is a sensitive but non-discriminatory marker of childhood encephalitis. We highlight the EEG features that predict abnormal outcome and DRE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 127, Issue 10, October 2016, Pages 3217-3224
نویسندگان
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