کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1983467 | 1539879 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biological factors underlying sex differences in neurological disorders
ترجمه فارسی عنوان
عوامل بیولوژیکی تفاوت های جنسیتی در اختلالات عصبی
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کلمات کلیدی
VTAGADD45γSex-determining Region on the Y ChromosomeD1RVMATMAO6-OHDACOMTMPTPSubstantia nigra pars reticulataD2RSNRDATSNCDBH6-Hydroxydopamine1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineddC - DDCdopa decarboxylase - dopa dearboxylaseattention-deficit hyperactivity disorder - اختلال بیش فعالی کمبود توجهautism spectrum disorders - اختلالات طیف اوتیسمDopamine transporter - انتقال دهنده دوپامینADHD - بیشفعالیParkinson's disease - بیماری پارکینسونsubstantia nigra pars compacta - توده سیاه پارس متراکمtyrosine hydroxylase - تیروزین هیدروکسیلازVesicular monoamine transporter - حامل مونوآمین VesicularSpontaneously Hypertensive Rat - خودآزمایی موش بالینیDopamine - دوپامینdopamine β-hydroxylase - دوپامین β-هیدروکسیلازSry - سوریShr - شریgenome wide association studies - مطالعات ارتباط گسترده ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومmonoamine oxidase - مونوآمین اکسیدازها ventral tegmental area - ناحیه تگمنتوم شکمیASD - نقص سپتوم یا دیوارهی دهلیزیnoradrenaline - نورآدرنالین catechol-o-methyl transferase - کاتچول-ات-متیل ترانسفرازcatecholamines - کاتکول امینDopamine D1 receptor - گیرنده Dopamine D1dopamine D2 receptor - گیرنده دوپامین D2Y-Chromosome - ی کروموزوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The prevalence, age of onset, pathophysiology, and symptomatology of many neurological and neuropsychiatric conditions differ significantly between males and females. Females suffer more from mood disorders such as depression and anxiety, whereas males are more susceptible to deficits in the dopamine system including Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), schizophrenia, and autism spectrum disorders (ASD). Until recently, these sex differences have been explained solely by the neuroprotective actions of sex hormones in females. Emerging evidence however indicates that the sex chromosome genes (i.e. X- and Y-linked genes) also contribute to brain sex differences. In particular, the Y-chromosome gene, SRY (Sex-determining Region on the Y chromosome) is an interesting candidate as it is expressed in dopamine-abundant brain regions, where it regulates dopamine biosynthesis and dopamine-mediated functions such as voluntary movement in males. Furthermore, SRY expression is dysregulated in a toxin-induced model of PD, suggesting a role for SRY in the pathogenesis of dopamine cells. Taken together, these studies highlight the importance of understanding the interplay between sex-specific hormones and sex-specific genes in healthy and diseased brain. In particular, better understanding of regulation and function of SRY in the male brain could provide entirely novel and important insights into genetic factors involved in the susceptibility of men to neurological disorders, as well as development of novel sex-specific therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 65, August 2015, Pages 139-150
Journal: The International Journal of Biochemistry & Cell Biology - Volume 65, August 2015, Pages 139-150
نویسندگان
Hannah Loke, Vincent Harley, Joohyung Lee,