کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10138264 | 1645886 | 2019 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal vitamin D deficiency does not exacerbate behavioural impairments associated with prenatal ethanol exposure in juvenile male mice
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کلمات کلیدی
DOPACdopamine 1 receptorPVDMAOAVMAT2HPRT1PREEUSVD1RVTACOMTNurr1D2RAADCDARPP-32UVB25(OH)D - 25 (OH) D3,4-dihydroxyphenylacetic acid - 3،4-دی هیدروکسی فنیل اسیدهای اسیدp57Kip2 - P57Kip2aromatic l-amino acid decarboxylase - آمونیوم اسید dearboxylaseattention deficit hyperactivity disorder - اختلال کمتوجّهی _ بیشفعالیAutism spectrum disorder - اختلالات طیف اوتیسم گروهیγ-aminobutyric acid - اسید γ-آمینوبوتیریکultraviolet B - اشعه ماوراء بنفش BADHD - بیشفعالیtyrosine hydroxylase - تیروزین هیدروکسیلازDopamine - دوپامینdopamine 2 receptor - دوپامین 2 گیرندهgestational day - روز بارداریWorld Health Organization - سازمان بهداشت جهانیultrasonic vocalizations - فراخوانهای اولتراسونیکPrenatal ethanol exposure - قرار گرفتن در معرض اتانول پیش از قاعدگیmonoamine oxidase A - مونوآمین اکسیداز Avesicular monoamine transporter 2 - مونوآمین حامل 2ventral tegmental area - ناحیه تگمنتوم شکمیASD - نقص سپتوم یا دیوارهی دهلیزیhomovanillic acid - هومووانیلیک اسیدhypoxanthine guanine phosphoribosyl transferase - هیپوکسانتین گوانین فسفریبوسیل ترانسفرازinternational units - واحدهای بین المللیHVA - چهVitamin D deficiency - کمبود ویتامین DWHO - کهGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
There is a high prevalence of vitamin D deficiency and exposure to low levels of ethanol in pregnant women. However, there are a paucity of studies that have addressed the impact of both vitamin D deficiency and ethanol exposure on the offspring's vulnerability to neurodevelopmental disorders later in life. The aim of this study was to examine whether the absence of vitamin D during gestation in mice would alter the effects of prenatal exposure to low dose ethanol on the behaviour and dopaminergic gene expression patterns of juvenile mice. Four-week old female C57BL/6J mice were placed on a prenatal vitamin D deficient (PVD) or standard diet for 6 weeks and mated at 10 weeks of age. Females were exposed to either 10%(v/v) ethanol or water between gestational days 0-8 and all were offered water thereafter. We found that blood ethanol concentration in the dams was not affected by maternal diet. Behavioural analyses of the offspring included ultrasonic vocalizations (USV) at postnatal day (P) 7, locomotion and social interaction at P21. The main findings were increased USV calling rate and impaired social interaction in males with prenatal ethanol exposure (PrEE). Gene expression analysis of transcripts involved in dopamine regulation revealed a main effect of ethanol exposure on dopamine- and cyclic adenosine monophosphate- regulated neuronal phosphoprotein (Darpp-32), a main effect of vitamin D diet on Dopamine 2 Receptors (D2R) and a main effect of Sex on Tyrosine Hydroxylase (TH) expression. The combination of PVD-PrEE did not exacerbate the alterations resulting from PVD or PrEE. Despite the limited evidence to support the interaction of PVD and PrEE during the postnatal period, males were more vulnerable than female offspring to the detrimental effects of PrEE. Therefore, based on these studies in mice we suggest that maintenance of optimal vitamin D levels and abstinence from ethanol during pregnancy would reduce risk of later disruption to brain function and behaviour in the offspring.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 356, 1 January 2019, Pages 127-136
Journal: Behavioural Brain Research - Volume 356, 1 January 2019, Pages 127-136
نویسندگان
M.C. Sanchez Vega, S. Chong, T.H.J. Burne,