Novel imidazo[2,1-b]-1,3,4-thiadiazoles as promising antifungal agents against clinical isolate of Cryptococcus neoformans

Novel hybrids including chalcones (5a-o) and Schiff bases (6a-j) of imidazo[2,1-b]-1,3,4-thiadiazole scaffold were synthesized and evaluated against clinical isolate of Cryptococcus neoformans.