Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization

A novel series of diarylnicotinamide derivatives (DANAs) were rationally designed synthesized and evaluated as inhibitors of HIV-1 wild-type and double mutant (K103N + Y181C) RES056 strains.