دانلود مقالات ISI درباره Nnrtis + ترجمه فارسی

مهارکننده های پروتئینی سرین و برنامه های درمانی آنها

Microbial serine protease inhibitors and their therapeutic applications

Keywords: A2Ms; α-2- macroglobulins; AFLEI; elastase inhibitor from Aspergillus flavus; AFUEI; elastase inhibitor from Aspergillus fumigatus; AP; α-2-antiplasmin; AT; antithrombin; bFGF; basic fibroblast growth factor; BSuPI; Bacillus subtilis protease inhibitor;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

دوست یا دشمن؟ تلومراز به عنوان یک هدف دارویی در سرطان و بیماری های قلبی عروقی

Friend or foe? Telomerase as a pharmacological target in cancer and cardiovascular disease

Keywords: ALS; amyotrophic lateral sclerosis; ALT; alternative telomere lengthening mechanisms; ARIC; Atherosclerosis risk in communities; BP; blood pressure; CAD; coronary artery disease; CML; chronic myelogenous leukemia; CVD; cardiovascular disease; EC; endothel

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

از ویروس نقص ایمنی بدن ویروس غیر نوکلئوزید مهار کننده ترانس کریتاز معکوس به ترکیبات قوی و انتخابی آنتی تری پانوسوم

From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds

Keywords: African trypanosomiasis; Trypanosoma brucei; Antitrypanosomal activity; NNRTIs; Triazines;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents

Keywords: HIV; NNRTIs; SG-1; Structure-activity relationship; NNRTI-resistant;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2

Keywords: HIV-1; HIV-2; NNRTIs; DAPY; Drug design; Entrance channel;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

Keywords: HIV-1; NNRTIs; Triazole; Diarylnicotinamide; Entrance channel; Drug design;

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Oxygen binding isotope effects of triazole-based HIV-1 reverse transcriptase inhibitors indicate the actual binding site

Keywords: HIV-1 reverse transcriptase; Binding isotope effects; QM/MM; FEP; Free energy of binding; Interaction energy; Potential energy; NNRTIs; HAART; Triazole-based RTIs;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs

Keywords: HIV-1; NNRTIs; Pyridine; Bioisosteric principle; Drug design;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement

Keywords: HIV; NNRTIs; Indolylarylsulfones; Antiviral activity; SAR; Molecular modeling; Chemical space; Drug design;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Prevalence of drug resistance among HIV-1 treatment-naive patients in Greece during 2003-2015: Transmitted drug resistance is due to onward transmissions

Keywords: cART; combination antiretroviral therapy; COMET; COntext-based modeling for expeditious typing; CPR; calibrated population resistance; CRFs; circulating recombinant forms; GTR; general time-reversible; HCDCP; Hellenic Center for Disease Control and Preven

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization

Keywords: NNRTIs; DAPYs; Uracil; Molecular hybridization; Physicochemical properties; Drug design;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach

Keywords: HIV-1; AIDS; NNRTIs; Purinylthioacetanilide; Anti-HIV activity; Drug design; Bioisosterism

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

1,6-Bis[(benzyloxy)methyl]uracil derivatives—Novel antivirals with activity against HIV-1 and influenza H1N1 virus

Keywords: Uracil; Non-nucleoside reverse transcriptase inhibitors; NNRTIs; HIV; Influenza virus

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1

Keywords: Diarylpyrimidine (DAPY); Etravirine; Human immunodeficiency virus (HIV); Non-nucleoside reverse transcriptase inhibitors; NNRTIs; Rilpivirine

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket

Keywords: HIV-1; NNRTIs; DAPY; Molecular hybridization; Drug design; Entrance channel

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Computer-aided discovery of anti-HIV agents

Keywords: Structure-based design; Free energy perturbation; Anti-HIV drugs; NNRTIs;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry

Keywords: AIDS; Efavirenz; Reverse transcriptase; Structure-activity relationship; Synthesis; HIV; NNRTIs;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Untangling the Gordian knot of HIV, stress, and cognitive impairment

Keywords: HIV; Stress; Inflammation; CD4; Cognition; IL-1β; Interleukin-1β; IL-2; Interleukin-2; IL-6; Interleukin-6; IL-12; Interleukin-12; IL-18; Interleukin-18; ACTH; Adrenocorticotropic hormone; AIDS; Acquired immune deficiency syndrome; ANI; Asymptomatic neu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines

Keywords: HIV-1 RT; Imidazo[1,2-a]pyrazines; Core-refining; NNRTIs; Biological activity; Molecular simulation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of DAPY–DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Keywords: NNRTIs; DAPYs; DPEs; Molecular hybridization; Hybrids

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs

Keywords: HIV; human immunodeficiency virus; NNRTIs; non-nucleoside reverse transcriptase inhibitors; SARs; structure and activity relationships; HAART; highly active antiretroviral therapy; RT; reverse transcriptase; NVP; nevirapine; DLV; delavirdine; EFV; efavire

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Scaffold hopping: Exploration of acetanilide-containing uracil analogues as potential NNRTIs

Keywords: Nonnucleoside reverse transcriptase; Inhibitors; NNRTIs; HIV; Uracil; Amide;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif

Keywords: HIV-1; NNRTIs; Arylthioacetanilides; SARs; Drug design; Drug-resistance;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Leptin in congenital and HIV-associated lipodystrophy

Keywords: POMC; pro-opiomelanocortin; NPY; neuropeptide Y; MRI; magnetic resonance imaging; AMPK; adenosine monophosphate-activated protein kinase; HIV; Human Immunodeficiency Virus; HALS; HIV-associated lipodystrophy syndrome; CT; computed tomography; DEXA; dual-e

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold

Keywords: CCR5; CC chemokine receptor type 5; CXCR4; CXC chemokine receptor type 4; MAGI; multinuclear activation of a galactosidase indicator; NNRTIs; non-nucleoside reverse transcriptase inhibitors; NRTIs; nucleoside reverse transcriptase inhibitors; PIs; proteas

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2015 سفارش ترجمه

Novel indole based NNRTIs with improved potency against wild type and resistant HIV

Keywords: HIV; NNRTIs; AIDS; Indole

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Keywords: Anti-HIV agents; Diarylaniline; NNRTIs; Physicochemical property;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Development of a cost-effective assay for genotyping of HIV-1 non-B subtype for drug resistance

Keywords: HAART; Highly Active Antiretroviral Therapy; NRTIs; Nucleoside/Nucleotide Reverse Transcriptase Inhibitors; NNRTIs; Non-Nucleoside Reverse Transcriptase Inhibitors; Genotype; Drug resistance; HIV-1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors

Keywords: HIV-1; NNRTIs; Diarylpyrimidine; SAR; Antiviral activity

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors

Keywords: HIV-1; NNRTIs; Diarylpyrimidine; SAR; Antiviral activity

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach

Keywords: HIV-1; Reverse transcriptase; NNRTIs; Drug design; Organic synthesis; Pyridine; Bioactivity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors

Keywords: HIV; NNRTIs; Pyrimidine; Antiviral activity; Drug design; SAR; SCR; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives

Keywords: BSZRGJKRHYXHIP-UHFFFAOYSA-N; JLTOSZWUKFGEJV-UHFFFAOYSA-N; WVZNAGYRPXFMRY-UHFFFAOYSA-N; ULRBWXYDRJNLNG-UHFFFAOYSA-N; YXLLVZNNNCCREE-UHFFFAOYSA-N; FYEKUVZLJJCIGP-UHFFFAOYSA-N; IYCQWQGKUDDQGF-UHFFFAOYSA-N; RZMXRCFAAJREMJ-UHFFFAOYSA-N; GYBQBADMBRADDS-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Design and synthesis of N1-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

Keywords: HIV-1 reverse transcriptase; NNRTIs; N1-Aryl-benzimidazoles 2-substituted; Synthesis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays

Keywords: NNRTIs; HIV; Drug design; 2-Pyridone; Molecular hybridization; Docking

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs

Keywords: HIV-1; AIDS; NNRTIs; Synthesis; Anti-HIV-1 activity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization

Keywords: HIV-1; NNRTIs; DANAs; Entrance channel; Molecular hybridization; Drug design;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Rational design and synthesis of novel thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors

Keywords: Thiazolidin-4-ones; Anti-HIV-1 activity; HIV-1 reverse transcriptase; NNRTIs

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies

Keywords: HIV-1 reverse transcriptase; NNRTIs; S-DABO; SAR; Rigid conformation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs

Keywords: HIV; Reverse transcriptase; NNRTIs; Thienothiadiazine; Pyrrolothiatriazine; Heterocycle; Drug design;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents

Keywords: Anti-HIV-1 agents; NNRTIs; Uracil analogs; Molecular modeling analysis; HIV-1 RT;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs

Keywords: HIV-1; AIDS; NNRTIs; Pyridazine derivatives; Anti-HIV-1 activity;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs

Keywords: Pyrimidine; Anti-HIV activity; NNRTIs; HIV-1; Reverse transcriptase;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2013 سفارش ترجمه

Bifunctional inhibition of HIV-1 reverse transcriptase: A first step in designing a bifunctional triphosphate

Keywords: HIV-1; human immunodeficiency virus type 1; RT; reverse transcriptase; NRTIs; nucleoside RT inhibitors; NNRTIs; nonnucleoside RT inhibitors; dNTP; deoxynucleoside triphosphate; dNMP; 3′-deoxynucleoside monophosphate; PPi; pyrophosphate; AZT; β-d-(+)-3â

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2013 سفارش ترجمه

Selection and characterization of viruses resistant to the dual acting pyrimidinedione entry and non-nucleoside reverse transcriptase inhibitor IQP-0410

Keywords: HIV; Resistance; Pyrimidinediones; NNRTIs;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2013 سفارش ترجمه

Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency

Keywords: Anti-HIV agents; Computer-aided drug design; NNRTIs; Free-energy calculations

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase

Keywords: Nonnucleoside reverse transcriptase inhibitors; NNRTIs; HIV; Uracil; Benzophenone; Cinnamyl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors

Keywords: HIV-1; NNRTIs; Diarylpyrimidine; Benzophenone; Molecular hybridization; Antiviral activityNNRTIs, non-nucleoside reverse transcriptase inhibitors; DAPYs, diarylpyrimidine derivatives; BPs, benzophenone derivatives; NVP, nevirapine; DLV, delavirdine; HIV-1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors

Keywords: Diarylaniline; NNRTIs; Lead optimization; Anti-HIV agents

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents

Keywords: HIV-1 reverse transcriptase; NNRTIs; Anti-HIV-1 activity; Triazines; Triazine dimers;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه