Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors

A novel series of non-nucleoside reverse transcriptase inhibitors with pyrimidinylthioacetanilide scaffold was rationally designed, synthesized and evaluated for their anti-HIV activity in MT-4 cells.