Imidazo[2,1-b]thiazole derivatives as new inhibitors of 15-lipoxygenase

A series of 3,6-diphenylimidazo[2,1-b]thiazol-5-amines containing bulky 5-alkylamino residues were synthesized as 15-lipoxygenase inhibitors. The most active compound 5i bearing 5-(2,4,4-trimethylpentan-2-ylamino) group was 2-fold more potent than reference drug quercetin.