Polyoxygenated cinnamoylcoumarins as conformationally constrained analogs of cytotoxic diarylpentanoids: Synthesis and biological activity

A series of cinnamoylcoumarins was designed and synthesized as conformationally constrained analogs of cytotoxic diarylpentanoids. Among them, 7-hydroxycoumarin 6h showed good antiproliferative activity against all tested cell lines.