In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4

Amongst the synthesized compounds, the best rounding up activity was obtained with compounds 11 and 19 (R1 = R2 = R3 = R6 = OCH3, R4 = R5 = H, R7 = OH) with concentrations of 0.13 and 0.2 μM, respectively.