Keywords: پلیمریزاسیون توبولین; 3,4,5-Trimethoxyphenyl fragment; G2/M; Apoptosis; ÎΨ; Tubulin polymerization; Colchicine site;
مقالات ISI پلیمریزاسیون توبولین (ترجمه نشده)
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Keywords: پلیمریزاسیون توبولین; Indole-pyrimidine; Morpholine; Thiomorpholine; Antiproliferative activity; Tubulin polymerization;
Keywords: پلیمریزاسیون توبولین; Epidermal growth factor receptor (EGFR); BRAF; Focal adhesion kinase (FAK); Tubulin polymerization; Cancer cell lines; MDR; multidrug resistance; EGFR; epidermal growth factor receptor; EMEA; European Medicines Evaluation Agency; FDA; US Food and Drug Adm
Keywords: پلیمریزاسیون توبولین; Quinolines; Tubulin polymerization; Anticancer activity; Molecular docking; Resistant cancer cells
Keywords: پلیمریزاسیون توبولین; Triazoloquinazolinone; Combretastatin; Tubulin polymerization; Cytotoxicity; Antivascular
Keywords: پلیمریزاسیون توبولین; Chalcones; 1,3-Diaryl-2-propen-1-ones; Anti-cancer; Cytotoxic activity; Tubulin polymerization;
Keywords: پلیمریزاسیون توبولین; FBS; fetal bovine serum; ATCC; American type cell culture; MTT; tetrazolium bromide solution; DNA; deoxyribonucleic acid; DMSO; dimethylsulfoxide; IC50; inhibitory concentration 50%; Nos; noscapine; EM011; bromonoscapine; PBS; phosphate buffered saline; K
Keywords: پلیمریزاسیون توبولین; Curcumin analogs; In silico molecular docking; Anti proliferative activity; Tubulin polymerization
Keywords: پلیمریزاسیون توبولین; 1,2,3,4-Tetrahydroisoquinolines (THIQ); Tubulin polymerization; Cell cycle analysis; Caspase-3; Annexin V-FITC assay and apoptosis
Keywords: پلیمریزاسیون توبولین; Tubulin polymerization; Apoptosis; Caspase-3; Hoechst staining; FACS analysis
Keywords: پلیمریزاسیون توبولین; Synthesis; Anticancer activity; Indole; Tubulin polymerization; Colchicine binding; Apoptosis; Cell cycle arrest; Molecular docking
Keywords: پلیمریزاسیون توبولین; Tubulin polymerization; Tubulin polymerization inhibitors; Microtubules; Disruption of microtubules;
Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors
Keywords: پلیمریزاسیون توبولین; Pyrrol-2(3H)-ones; Pyridazin-3(2H)-ones; Quinoline; Antiproliferative; Tubulin polymerization; BRAF Kinase;
Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells
Keywords: پلیمریزاسیون توبولین; Anticancer activity; Pt(IV) complex; Tubulin polymerization; Apoptosis;
Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells
Keywords: پلیمریزاسیون توبولین; 4-Phenylcoumarins; Thiazole; MCF-7; Tubulin polymerization; Apoptosis; Molecular modeling;
Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability
Keywords: پلیمریزاسیون توبولین; Imidazothiadiazoles; Cell cycle; Cytotoxicity; Tubulin polymerization; Apoptosis;
3-Aryl/Heteroaryl-5-amino-1-(3â²,4â²,5â²-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization
Keywords: پلیمریزاسیون توبولین; Microtubule targeting-agent; Structure-activity relationship; Tubulin polymerization; Antiproliferative activity; Molecular docking;
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Keywords: پلیمریزاسیون توبولین; 1,4-Diaryl-2-azetidinone; Combretastatin A-4; Tubulin polymerization; Antitumor; SAR; structure-activity relationship; DABCO; 1,4-diazabicyclo[2.2.2]octane; TBAF; tetrabutylammonium fluoride; NMO; 4-methylmorpholine N-oxide; TBAB; tetrabutylammonium bromi
One-pot synthesis and biological evaluation of N-(aminosulfonyl)-4-podophyllotoxin carbamates as potential anticancer agents
Keywords: پلیمریزاسیون توبولین; Podophyllotoxin; Tubulin polymerization; Microtubule assembly; Apoptosis; Cell cycle arrest;
Design and synthesis of 4-morpholino-6-(1,2,3,6-tetrahydropyridin-4-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine analogues as tubulin polymerization inhibitors
Keywords: پلیمریزاسیون توبولین; 1,3,5-Triazine; Morpholine; Antiproliferative activity; Tubulin polymerization; Molecular docking study;
Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents
Keywords: پلیمریزاسیون توبولین; E7010; Benzothiazole; Cytotoxicity; Cell cycle; Tubulin polymerization;
Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents
Keywords: پلیمریزاسیون توبولین; Hydantoin; CA-4 analogue; Anticancer; Tubulin polymerization;
New indole-based chalconoids as tubulin-targeting antiproliferative agents
Keywords: پلیمریزاسیون توبولین; Chalcones; 1,3-Diaryl-2-propen-1-ones; Indole; Anticancer; Cytotoxic activity; Tubulin polymerization;
Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance
Keywords: پلیمریزاسیون توبولین; Antitumor activity; Pt(IV) complex; Tubulin polymerization; Apoptosis;
Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers
Keywords: پلیمریزاسیون توبولین; Combretastatin A-4; Benzothiazole; Triazoles and tetrazoles; Antiproliferative activity; Tubulin polymerization; Colchicine competition assay; Apoptosis;
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics
Keywords: پلیمریزاسیون توبولین; Triazolo[4,5-b/c]pyridin-acrylonitriles; Antiproliferative activity; Tubulin polymerization; Molecular modeling; Isothermal titration calorimetry; Fluorescence-based assays;
4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin
Keywords: پلیمریزاسیون توبولین; Combretastatin A-4/oltipraz hybrids; Antiproliferative activity; Tubulin polymerization; Cell cycle arrest; Molecular modelling studies
Cytotoxic biphenyl-4-carboxylic acid targets the tubulin-microtubule system and inhibits cellular migration in HeLa cells
Keywords: پلیمریزاسیون توبولین; Biphenyl-4-carboxylic acid; Biphenyl-2-carboxylic acid; Tubulin polymerization; Antimitotic compound; HeLa;
Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors
Keywords: پلیمریزاسیون توبولین; 1,3,4-Oxadiazole; Tubulin polymerization; Apoptotic cell death; Colchicine binding; Molecular modeling
Synthesis and biological evaluation of arylcinnamide linked combretastatin-A4 hybrids as tubulin polymerization inhibitors and apoptosis inducing agents
Keywords: پلیمریزاسیون توبولین; CA-4; Cinnamides; Conjugate; Cytotoxicity; Cell cycle; Tubulin polymerization;
Synthesis and Biological evaluation of novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxins as anticancer compounds
Keywords: پلیمریزاسیون توبولین; Tetrazolyl podophyllotoxin; Anticancer activity; Tubulin polymerization
Synthesis and biological evaluation of benzimidazole-oxindole conjugates as microtubule-targeting agents
Keywords: پلیمریزاسیون توبولین; Benzimidazoles-oxindoles; Cytotoxic activity; Cell cycle; Tubulin polymerization; Docking;
Synthesis of 2-aryl-1,2,4-oxadiazolo-benzimidazoles: Tubulin polymerization inhibitors and apoptosis inducing agents
Keywords: پلیمریزاسیون توبولین; Benzimidazole; 1,2,4-Oxadiazole; Cytotoxicity; Tubulin polymerization; Apoptosis; Molecular docking;
Synthesis of arylpyrazole linked benzimidazole conjugates as potential microtubule disruptors
Keywords: پلیمریزاسیون توبولین; Anticancer; Caspase-3; Molecular modeling; Pyrazole-benzimidazole conjugates; Tubulin polymerization;
A new synthetic 2′-hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone induces G2/M cell cycle arrest and apoptosis by disrupting the microtubular network of human colon cancer cells
Keywords: پلیمریزاسیون توبولین; 2′-Hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone; Tubulin polymerization; G2/M arrest; Apoptosis; Caspase-2
Syntheses and antiproliferative effects of d-homo- and d-secoestrones
Keywords: پلیمریزاسیون توبولین; Homoestrone; Secoestrone; Antiproliferative effect; MTT assay; Tubulin polymerization
Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors
Keywords: پلیمریزاسیون توبولین; Podophyllotoxin; Benzimidazole; Cytotoxicity; Tubulin polymerization; Molecular docking;
Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors
Keywords: پلیمریزاسیون توبولین; 4-Azapodophyllotoxin; 1,10-Phenanthroline; Multicomponent reaction; Cytotoxicity; Tubulin polymerization;
Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity
Keywords: پلیمریزاسیون توبولین; Pyrrolo[3,4-h]quinazolines; Antiproliferative activity; Antimitotic activity; Tubulin polymerization; Vascular disrupting activity; AO; acridine orange; EGFR; Epidermal Growth Factor Receptor; FITC; fluorescein isothiocyanate; H2DCFDA; 2â²,7â²-dichlorod
Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents
Keywords: پلیمریزاسیون توبولین; Microtubules; E7010; 2-Anilinopyridine; Dimers; Tubulin polymerization; Apoptosis;
Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization
Keywords: پلیمریزاسیون توبولین; E7010; Cell cycle; Cytotoxicity; Triazoles; Tubulin polymerization;
Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers
Keywords: پلیمریزاسیون توبولین; CA-4; Cell cycle; Cytotoxicity; Triazoles; Tubulin polymerization;
Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs
Keywords: پلیمریزاسیون توبولین; Anticancer activity; Cytotoxicity; Combretastatin analogs; 2(3H)-Thiazole thiones; Thiazolidine-2-thione; Tubulin polymerization;
Design, synthesis, cytotoxic evaluation and tubulin inhibitory activity of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazole derivatives
Keywords: پلیمریزاسیون توبولین; Cytotoxicity activity; Cell cycle analysis; Tubulin polymerization; Tautomerization; 2-Alkylthio-1H-imidazole
MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity
Keywords: پلیمریزاسیون توبولین; Tripentone; FLT3; FLT3-ITD; Tubulin polymerization
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives
Keywords: پلیمریزاسیون توبولین; Acridinone; Phenothiazine; Tubulin polymerization; Cytotoxicity
Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents
Keywords: پلیمریزاسیون توبولین; Biaryl aryl stilbenes; Biaryl aryl ethylenes; Antimicrotubule agents; Tubulin polymerization; Antiproliferative activity
Copper(I) mediated facile synthesis of potent tubulin polymerization inhibitor, 9-amino-α-noscapine from natural α-noscapine
Keywords: پلیمریزاسیون توبولین; Noscapine; Amino-noscapine; Copper iodide; Tubulin polymerization; Isoquinoline alkaloid
Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors
Keywords: پلیمریزاسیون توبولین; Terphenyls; Suzuki coupling; Benzimidazoles; Anticancer agents; Tubulin polymerization
In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4
Keywords: پلیمریزاسیون توبولین; Antivascular agents; Combretastatin analogs; Triazoles; Endothelial cells; Tubulin polymerization; Cytotoxicity;