Aminoacyl-tRNA synthetase inhibitors as potential antibiotics

► Aminoacyl tRNA synthetases (aaRSs) are a key component in protein synthesis. ► AaRS inhibitors make up a potential class of new antimicrobials. ► Several aaRS inhibitors are in clinical development. ► Aminoacyl sulfamoyladenosines (aaSAs) for a long time already have been evaluated as high-potential antibiotics. ► Improvement of the bioavailability problem of aaSAs is under investigation. ► The here discussed compounds will further establish aaRSs as a valuable target for development of antibiotics.