l-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies

► Synthesis and characterization of novel pyrido[2,3-a]carbazoles. ► Few compounds show significant antibacterial activity. ► 5f is active than cisplatin against A-549, HCT-15, SKMel2 and B16F10 cell lines. ► 5e is active than cisplatin A-549, HCT-15, SKMel2 cell lines. ► Preliminary Structure-activity relationship for Antibacterial and Cytotoxicity.