Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity

► Efficient synthesis of aminopyrimidines is reported. ► 3-Aminophenyl substituted pyrimidine showed good inhibition of Mycobacterium tuberculosis. ► Varied inhibition of proliferation of human carcinoma cells lines was observed.