کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7865679 | 1509128 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Y-shaped copolymers of poly(ethylene glycol)-poly(ε-caprolactone) with ketal bond as the branchpoint for drug delivery
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Y-shaped copolymers of poly(ethylene glycol)-poly(ε-caprolactone) with ketal bond as the branchpoint for drug delivery Y-shaped copolymers of poly(ethylene glycol)-poly(ε-caprolactone) with ketal bond as the branchpoint for drug delivery](/preview/png/7865679.png)
چکیده انگلیسی
In this study, a Y-shaped amphiphilic block copolymer consisting of hydrophilic poly(ethylene glycol) (mPEG) and two poly(ε-caprolactone) (PCL) as the hydrophobic arms with a ketal linker was synthesized (mPEG-Ketal-(PCL)2). The structure of the copolymer with different compositions was characterized by 1H NMR, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). The amphiphilic property endows the copolymer with the ability to be self-assembled into micelles for encapsulating anticancer drug doxorubicin (DOX), and the effect of copolymer with different PCL length on drug loading properties were tested. The morphology, size, pH responsiveness, drug release profile and in vitro anticancer activity of the DOX loaded micelles were also studied. In vitro drug release studies showed that over 50% of the DOX was released at pHâ¯5.0 in 24â¯h because of hydrolysis of ketal linker in the copolymers. The confocal laser microscopy and flow cytometry experiments showed that the DOX-loaded micelles could be effectively internalized by Hela cells, the ketal bond in the backbone was broken in acid endo/lysosomal compartments and triggered the fast release of DOX. The in vitro antitumor efficacy of the DOX loaded mPEG-Ketal-(PCL)2 micelles was better than that of non-pH sensitive ones. In vivo studies showed that the mPEG-Ketal-(PCL)2 micelles enhanced the DOX blood circulation time and had good tumor-targeting efficiency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 93, 1 December 2018, Pages 554-564
Journal: Materials Science and Engineering: C - Volume 93, 1 December 2018, Pages 554-564
نویسندگان
Yujiao Zhang, Yujie Lu, Ming Cao, Peng Chen, Bin Yang, Jibin Miao, Ru Xia, Jiasheng Qian,