کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7865857 | 1509131 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dextran coated Fe3O4 nanoparticles as a near-infrared laser-driven photothermal agent for efficient ablation of cancer cells in vitro and in vivo
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dextran coated Fe3O4 nanoparticles as a near-infrared laser-driven photothermal agent for efficient ablation of cancer cells in vitro and in vivo Dextran coated Fe3O4 nanoparticles as a near-infrared laser-driven photothermal agent for efficient ablation of cancer cells in vitro and in vivo](/preview/png/7865857.png)
چکیده انگلیسی
The photothermal effect of dextran coated Fe3O4 nanoparticles for cancer therapy is investigated in this work. The dextran/Fe3O4 nanoparticles were prepared by coprecipitation method. Results demonstrated that the dextran not only isolated the interior Fe3O4 nanoparticles from oxygen and water to enhance the photothermal stability, but also enhanced the biocompatibility of Fe3O4 nanoparticles. In vitro experiments indicated that dextran/Fe3O4 nanoparticles showed low toxicity to cells without any irradation. After near-infrared (NIR) laser irradiation, however, the viabilities of tumor cells were effectively suppressed. Further in vivo experimental studies found that mice tumor growth was significantly inhibited by the photothermal effect of dextran/Fe3O4 nanoparticles. After 28â¯days the tumor was completely cleared. These dextran/Fe3O4 nanoparticles have biosecurity and high photothermal efficiency at the same time, thus promising high clinical potential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 90, 1 September 2018, Pages 46-56
Journal: Materials Science and Engineering: C - Volume 90, 1 September 2018, Pages 46-56
نویسندگان
Fei Wang, Xinshi Li, Wentao Li, Hua Bai, Yue Gao, Jiahua Ma, Wei Liu, Guangcheng Xi,