کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7866367 1509133 2018 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
One-step fabrication of functionalized poly(etheretherketone) surfaces with enhanced biocompatibility and osteogenic activity
ترجمه فارسی عنوان
ساخت یک مرحله ای از سطوح پلی اتیل ورتکتون با عملکرد زیست سازگاری و فعالیت استئوژنیک
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی
Polyetheretherketone (PEEK) has an elastic modulus similar to that of the bone; however, its use as a material for bone repair is limited by bio-inert surface chemistry and poor osteogenesis-inducing capacity. To address this issue, the PEEK surface was activated by ultraviolet radiation-induced grafting of methacrylated hyaluronic acid (MeHA) and titanium dioxide (TiO2) nanofibers via a one-step process. The modified PEEK surface was characterized by X-ray photoelectron and Fourier-transform infrared spectroscopy, and the extent of surface modification was evaluated by measuring static contact angles. Atomic force microscopy revealed that the PEEK surface grafted with electrospun TiO2 had abundant nanofibers and a roughness that was comparable to that of human cortical bone. In vitro experiment, rat bone mesenchymal stem cells showed increased adhesion, proliferation, and osteogenic differentiation capacity on TiO2-modified as compared to unmodified PEEK. Thus, PEEK that is surface-modified with electrospun TiO2 and MeHA has enhanced biocompatibility and can be an effective material for use in orthopedic implants and medical devices.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 88, 1 July 2018, Pages 70-78
نویسندگان
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