Effects of polycaprolactone on alendronate drug release from Mg-doped hydroxyapatite coating on titanium

(a) Pure CpTi substrate. (b) Deposition of Mg-HA on CpTi substrate using supersonic plasma nozzle. (c) Fully coated substrate loaded with alendronate then coated with PCL; both via drop by drop method. (d) Mg-HA coated CpTi implants with controlled alendronate release through PCL coating with initial burst release and sustained release over time.83