کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7867856 | 1509161 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Improved cellular response of ion modified poly(lactic acid-co-glycolic acid) substrates for mouse fibroblast cells
ترجمه فارسی عنوان
بهبود پاسخ سلولی پلی استایرن (اسید لاکتیک اسید-کل گلیکولیک اسید) اصلاح شده یون برای سلول های فیبروبلاست موس
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کلمات کلیدی
نانوکامپوزیتهای پلیمری، رشد سلولی، اموال سطحی،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
In this report, the effects of argon (Ar) ion irradiation on poly(lactic acid-co-glycolic acid) (PLGA) substrates on biocompatibility were studied. PLGA scaffold substrates were prepared by spin coating glass surfaces with PLGA dissolved in anhydrous chloroform. Previously, we showed that surface modifications of PLGA films using ion irradiation modulate the inherent hydrophobicity of PLGA surface. Here we show that with increasing ion dose (1Â ÃÂ 1012 to 1Â ÃÂ 1014Â ions/cm2), hydrophobicity and surface roughness decreased. Biocompatibility for NIH3T3 mouse fibroblast cells was increased by argon irradiation of PLGA substrates. On unirradiated PLGA films, fibroblasts had a longer doubling time and cell densities were 52% lower than controls after 48Â h in vitro. Argon irradiated PLGA substrates supported growth rates similar to control. Despite differences in cell cycle kinetics, there was no detectible cytotoxicity observed on any substrate. This demonstrates that argon ion irradiation can be used to tune the surface microstructure and generate substrates that are more compatible for the cell growth and proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 60, 1 March 2016, Pages 151-155
Journal: Materials Science and Engineering: C - Volume 60, 1 March 2016, Pages 151-155
نویسندگان
Ananta Raj Adhikari, Tanya Geranpayeh, Wei Kan Chu, Deborah C. Otteson,