کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7868256 | 1509160 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A fluorescent thermoresponsive polymer consisting of poly(N-vinylcaprolactam) (PVCL) coupled with carbon dots (CDs) (PVCL-CDs) was synthesized by reacting a carboxyl-terminated PVCL derivative with CDs via N-hydroxysuccinimide and N-(3-(dimethylamino)propyl)-N-ethylcarbodiimide hydrochloride coupling. The temperature-dependent fluorescence properties of this material were studied for biomedical applications. Fluorescence quenching in PVCL-CDs was observed above the lower critical solution temperature (LCST) due to thermo-induced aggregation of the PVCL chains. This fluorescent thermoresponsive PVCL-CDs showed good biocompatibility and was demonstrated as a thermometer for sensing intracellular temperatures and also as a marker for bioimaging. In addition, PVCL-CDs showed a significant fluorescence turn-on response to proteins above the LCST, which allows for the utilization of this material in biosensors. Thus, PVCL-CDs, with its tuneable size, low cytotoxicity, good photostability, ease of bioconjugation, and resistance to metabolic degradation, is a novel material for biomedical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 61, 1 April 2016, Pages 492-498
Journal: Materials Science and Engineering: C - Volume 61, 1 April 2016, Pages 492-498
نویسندگان
Thangavelu Kavitha, Jin-Oh Kim, Seungwook Jang, Dong-Pyo Kim, Inn-Kyu Kang, Soo-Young Park,